Antibody which binds to myelin oligodendrocyte glycoprotein
The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.
1. An antibody which binds to myelin oligodendrocyte glycoprotein (MOG) or an antibody fragment thereof, wherein the antibody comprises an antibody in which the amino acid sequences of complementarity determining regions (CDRs) 1 to 3 of the heavy chain variable region (VH) of the antibody comprise the amino acid sequences of SEQ ID NOs: 4, 5 and 6, respectively, and in which the amino acid sequences of CDRs 1 to 3 of the light chain variable region (VL) of the antibody comprise the amino acid sequences of SEQ ID NOs: 10, 11 and 12, respectively.
2. The antibody or the antibody fragment according to claim 1 , wherein the antibody comprises an antibody in which the amino acid sequence of VH comprises the amino acid sequence of SEQ ID NO: 3 and in which the amino acid sequence of VL comprises the amino acid sequence of SEQ ID NO: 9.
3. The antibody fragment according to claim 1 which is selected from the group consisting of Fab, Fab′, F(ab′) 2 , a single chain antibody (scFv), a dimerized V region (diabody), a disulfide-stabilized V region (dsFv), VHH, and a peptide comprising CDR.
4. The antibody or the antibody fragment according to claim 1 , wherein the antibody is a genetically recombinant antibody.
5. The antibody or the antibody fragment according to claim 1 , wherein the antibody is selected from the group consisting of a chimeric antibody, a humanized antibody, and a human antibody.
6. A composition which comprises the antibody or the antibody fragment according to claim 1 .
7. The composition according to claim 6 , wherein the composition further comprises a carrier or a stabilizing agent.
8. The composition according to claim 6 , wherein the composition further comprises one or more pharmacologically acceptable carriers.