Compounds and compositions
Disclosed are compounds having the following formula: (I) wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula: (Ia) wherein Ra and Rb are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3.
1. A compound having the following formula:
wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −2;
or R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3.
2. A compound according to claim 1 , wherein R is a saturated linear alkane chain having between 8 and 16 carbon atoms.
3. A compound according to claim 1 , wherein R a and R b are saturated linear alkane chains having between 8 and 16 carbon atoms.
4. A compound according to claim 1 , wherein the one or more anions are selected from chloride anions and bromide anions.
5. A compound according to claim 1 , having the following formula:
6. A compound having the following formula:
wherein R is an alkane chain having between 8 and 20 carbon atoms and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3; and wherein X is 2, 4, 6, 8 or 10.
7. A compound according to claim 6 , wherein R is a saturated linear alkane chain having between 8 and 16 carbon atoms.
8. A compound according to claim 6 , wherein R a and R b are saturated linear alkane chains having between 8 and 16 carbon atoms.
9. A compound according to claim 6 , wherein the one or more anions are selected from chloride anions and bromide anions.
10. A compound according to claim 6 , having the following formula:
wherein X is 4, 8 or 10.
11. A pharmaceutical composition comprising:
the compound of claim 1 or claim 6 ; and a pharmaceutically acceptable carrier.
12. A method of treatment of Herpes virus, Human Papilloma virus, fungal infections and/or bacterial infections, comprising a step of administering to a subject a compound according to claim 1 or claim 6 .
13. A process for producing the compound of claim 1 , comprising:
i) reacting carvacrol with R 2 CH 2 COCl to form a compound having the formula:
wherein R 2 is a halogen;
ii) reacting a compound having the formula
with the compound having the formula
to form the compound having the formula
wherein R is an alkane chain having between 8 and 20 carbon atoms; or
R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms;
iii) reacting thymol with R 2 CH 2 COCl to form a compound having the formula
wherein R 2 is a halogen;
iv) reacting the compound having formula
with the compound having the formula
to form the final product having the formula
wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3.
14. A process according to claim 13 , wherein R is a saturated linear alkane chain having between 8 and 16 carbon atoms.
15. A process according to claim 13 , wherein R a and R b are each a saturated linear alkane chain having between 8 and 16 carbon atoms.
16. A process according to claim 13 , further comprising one or more steps of separation and/or extraction.
17. A process for the production of a compound according to claim 6 , comprising reacting the compound having the formula
with bromine to form a compound having the formula
wherein R is an alkane chain having between 8 and 20 carbon atoms and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3; and wherein X is 2, 4, 6, 8 or 10.
18. A compound having the following formula:
wherein R is an alkane chain having between 8 and 20 carbon atoms and A is one or more anions having a total charge of −2; or R is a quaternary amine having the following formula:
wherein R a and R b are each an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of −3; and wherein the compound is complexed with bromine.