Automatic analysis device
An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.
1. An automatic analysis device, comprising:
a detector that analyzes a sample;
a probe that performs a dispensing operation including a suction process and a discharge process with respect to a liquid;
a syringe that generates a pressure change for dispensing the liquid at the probe;
a flow path that connects the probe and the syringe with each other;
a pressure sensor that measures the pressure change in the flow path at the time of dispensing the liquid;
a storage device configured to store a time-series pressure change when reference fluid is discharged as a reference discharge pressure waveform; and
a control device configured to determine whether or not there is an abnormality in the suction process of the sample from a relationship between
(1) a value of
(a) a difference or
(b) a ratio,
between
(c) the reference discharge pressure waveform and
(d) the pressure waveform at the time of discharge of the liquid and
(2) a value previously determined to be in a normal range,
wherein the storage device is configured to store a relationship between a time when the value first deviates from the value previously determined to be in the normal range and an amount of air mixed in the liquid for each preset dispensing amount, and
wherein the control device is configured to estimate the amount of air mixed in the liquid based on an amount of time from the time when the value first deviates from the value previously determined to be in the normal range until a time when the value returns to be within the value previously determined to be in the normal range.
2. The automatic analysis device according to claim 1 ,
wherein the storage device stores the reference discharge pressure waveform and the normal range for each set dispensing amount.
3. The automatic analysis device according to claim 1 ,
wherein the control device is configured to determine a cause of an abnormality based on an estimated amount of air contained in the sample.
4. The automatic analysis device according to claim 1 ,
wherein the reference discharge pressure waveform is any of a pressure waveform obtained at the time of discharge of a calibrator which is measured at the time of performing assay calibration, a pressure waveform obtained at the time of discharge of an accuracy management sample which is measured at the time of accuracy management measurement performance, a pressure waveform obtained at the time of discharge of purified water, or a pressure waveform obtained at the time of discharge of air.
5. The automatic analysis device according to claim 1 ,
wherein the reference discharge pressure waveform is acquired at any timing of at the time of shipping of the automatic analysis device, at the time of installation of the automatic analysis device, at the time of a preparation operation before analysis start, or before and after liquid is sucked and discharged.
6. The automatic analysis device according to claim 1 , further comprising:
a container for accommodating purified water as the reference fluid on a movement path of the probe.