Photoreactive ligands and uses thereof
Disclosed herein are methods for identifying proteins as targets for interaction with a small molecule ligand. Also disclosed herein are small molecule ligands and compositions for use in profiling druggable proteins.
1. A small molecule ligand having a structure represented by Formula (I):
wherein R is
and wherein the wavy lines indicate linkage to the carbonyl group of the structure of Formula (I).
2. A small molecule ligand which binds to a ligand binding site of Cathepsin B (CTSB), the small molecule ligand is, selected from the group consisting of
3. The small molecule ligand of claim 2 , wherein the ligand binding site is defined by the following residues: GQDHCGIESEVVAGIPR of the CTSB protein having the UniProtKB accession number P07858.