IP Library Granted Patent US 12,326,622
Granted Patent B2
US 12,326,622 · App. 16/480,973 · Granted Jun 10, 2025

Thermally tunable low broadband waveguides and related systems and methods

Inventors: Michal Lipson (New York, NY); Aseema Mohanty (New York, NY); Mohammad Amin Tadayon (Bronx, NY); Adam Kepecs (Cold Spring Harbor, NY); Qian Li (Cold Spring Harbor, NY); Xingchen Ji (New York, NY); Christine P. Hendon (Bronx, NY); Xinwen Yao (New York, NY)
Assignees: The Trustees of Columbia University in the City of New York; Cold Spring Harbor Laboratory
G02F1/0147A61N5/0601A61N5/0622G02F1/011A61N2005/063G02F2203/50
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,326,622
App. No.
16/480,973
Granted
Jun 10, 2025
Kind
B2
Abstract

Provided are devices that have a distal portion configured to be implanted in a brain of a subject. The distal portion includes one or more emitters configured to emit light in the visible spectrum. The device includes a proximal portion configured to be external to the brain of the subject while the distal portion is implanted, wherein the proximal portion includes at least one waveguide in optical communication with the one or more emitters. The at least one waveguide defines a cross-sectional width less than 500 nm. The at least one waveguide is optionally coupled to a heating element that is optionally configured to adjust a phase of light within the at least one waveguide.

Claims (19)

1. A device, comprising:

a distal portion configured to be implanted in a brain of a subject, the distal portion comprising a phased array of emitters configured to emit light in the visible spectrum, wherein each emitter in the array is independently switchable to enable emission from a selected emitter; and

a proximal portion configured to be external to the brain of the subject while the distal portion is implanted, wherein the proximal portion includes at least one waveguide in optical communication with the phased array of emitters the at least one waveguide defining a cross-sectional width less than 500 nm, wherein the at least one waveguide is coupled to a heating element configured to adjust a phase of light within the at least one waveguide,

wherein the proximal portion comprises an optical switch having an input arm, a first output arm, and a second output arm, and wherein the heating element is configured to adjust the phase of light within the at least one waveguide, between the first output arm and the second output arm, at a switching speed faster than about 1 ms.

2. The device of claim 1 , wherein the at least one waveguide comprises silicon nitride.

3. The device of claim 1 , wherein the at least one waveguide comprises Si3N4 and has a polygonal cross-sectional geometry.

4. The device of claim 1 , wherein the at least one waveguide defines at least a portion of the optical switch, and wherein the at least one waveguide is configured to direct light, responsive to the phase, into the first output arm, into the second output arm, or into both the first and second output arms.

5. The device of claim 4 , wherein the optical switch is an interferometer, and the at least one waveguide defines arms of the interferometer.

6. The device of claim 4 , wherein the optical switch comprises a cascaded network of optical switches that include a lead switch, in which network each optical switch except the lead optical switch has an input arm defined by an output arm of another one of the optical switches in the network, each optical switch in the network has first and second output arms that are each in optical communication with the one or more emitters, each optical switch is an interferometer, and each waveguide is coupled to a respective heating element configured to adjust the phase of the respective waveguide to independently switch emission from a selected emitter.

7. The device of claim 6 , wherein the network includes a terminal row of optical switches, and each first and second output arm of each optical switch in the terminal row is in optical communication with a respective one of the one or more emitters.

8. The device of claim 1 , wherein the one or more emitters are diffraction grating emitters.

9. The device of claim 1 , further comprising one or more electrodes associated with the one or more emitters, wherein one or more of the electrodes is configured to record neural activity.

10. The device of claim 1 , wherein the distal portion has a probe length less than one or more of 1.000 mm, 200 μm, or 100 μm.

11. The device of claim 1 , wherein the phased array of emitters receives single wavelength light from an input fiber.

12. The device of claim 6 , wherein a distance between the phased array of emitters and the cascaded network of optical switches is at least 4 mm.

13. The device of claim 1 , wherein the heating element induces at least one of phase tuning or beam steering.

14. The device of claim 1 , wherein the heating element adjust an imaging displacement.

15. The device of claim 10 , wherein the distal portion has a probe length less than 1.000 mm.

16. The device of claim 1 , wherein the phased array collectively produces single neuron excitation and recording resolution.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 12, 2024
From: KEPECS, ADAM
To: COLD SPRING HARBOR LABORATORY
Reel/Frame 067698/0801 →
CONFIRMATORY LICENSE Recorded Jan 8, 2020
From: COLUMBIA UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 051517/0128 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2019
From: LIPSON, MICHAL; MOHANTY, ASEEMA; TADAYON, MOHAMMAD AMIN; LI, QIAN
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 050428/0406 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2019
From: LIPSON, MICHAL; JI, XINGCHEN; TADAYON, MOHAMMAD AMIN; MOHANTY, ASEEMA; HENDON, CHRISTINE P.; YAO, XINWEN
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 050428/0568 →
Continuity (3)
Provisional Application 62450158 · Jan 25, 2017
Provisional Application 62451504 · Jan 27, 2017
Related Publication 20190391415A1 · Dec 26, 2019
References Cited (33)
US 5073024A · Valette et al. · 1991 [cited by applicant]
US 7203387B2 · Doan · 2007 [cited by applicant]
US 8554022B1 · Hochberg et al. · 2013 [cited by applicant]
US 8936630B2 · Denison et al. · 2015 [cited by applicant]
US 9238150B2 · Deisseroth et al. · 2016 [cited by applicant]
US 10004917B2 · Li · 2018 [cited by examiner]
US 20050047702A1 · Parker et al. · 2005 [cited by applicant]
US 20080306576A1 · Boyden et al. · 2008 [cited by applicant]
US 20110112591A1 · Seymour et al. · 2011 [cited by applicant]
US 20110230747A1 · Rogers et al. · 2011 [cited by applicant]
US 20120253261A1 · Poletto et al. · 2012 [cited by applicant]
US 20130085398A1 · Roukes · 2013 [cited by applicant]
US 20140142664A1 · Roukes · 2014 [cited by examiner]
US 20140362433A1 · Adams · 2014 [cited by examiner]
US 20150125111A1 · Orcutt et al. · 2015 [cited by applicant]
US 20150196773A1 · Brown et al. · 2015 [cited by applicant]
US 20160303384A1 · Sahin et al. · 2016 [cited by applicant]
US 20180173024A1 · McGreer · 2018 [cited by examiner]
EP 3020450A1 · 2016 [cited by applicant]
Buzsáki et al., “Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics”, Neuron, vol. 86, Issue 1, Apr. 8, 2015, pp. 92-105. [cited by applicant]
Fercher et al., “Optical coherence tomography”, J. Biomed. Opt., vol. 1, No. 2, Apr. 1996, pp. 157-173. [cited by applicant]
Lipson et al., “Brain Eager: A Nanophotonic Platform for Multisite Optical Activation in the Brain”, NSF Grant #: 1611090 , https://www.nsf.gov/awardsearch/showAward?AWD_ID=1611090&HistoricalAwards=false. [Only Abstract… [cited by applicant]
Moss et al., “New CMOS-compatible platforms based on silicon nitride and Hydex for nonlinear optics”, Nature Photonics, vol. 7, Jul. 2013, pp. 597-607. [cited by applicant]
Pisanello et al., “Multipoint-emitting optical fibers for spatially addressable In vivo optogenetics”, Neuron, vol. 82, Issue 6, Jun. 18, 2014, pp. 1245-1254. [cited by applicant]
Raval et al., “Nanophotonic phased array for visible light image projection”, 2016 IEEE Photonics Conference, Oct. 2016, pp. 206-207. [cited by applicant]
Renishaw plc. Interferometry explained., https://www.renishaw.com/en/interferometry-explained-7854. [cited by applicant]
Segev et al., “Highly Multiplexed Nanophotonic Probes With Independently Controllable Emitters for Optogenetic Brain Stimulation”, Conference on Lasers and Electro-Optics, JTh4B. Jun. 2, 2016. [cited by applicant]
Tadayon et al., “Integrated nanophotonic platform for high bandwidth and high resolution optogenetic excitation”, 2016 Conference on Lasers and Electro-Optics, Jun. 2016, pp. 1-2. [cited by applicant]
Heideman RG et al., Performance of a highly sensitive optical waveguide Mach-Zehnder interferometer immunosensor, Sensors and Actuators B: Chemical vol. 10 / Issue 3, pp. 209-217, Feb. 1993. [cited by applicant]
Liu Q et al, Highly sensitive Mach-Zehnder interferometer biosensor based on silicon nitride slot waveguide, Sensors and Actuators B: Chemical vol. 188, pp. 681-688, Nov. 2013. [cited by applicant]
Misiakos K et al, All-silicon monolithic Mach-Zehnder interferometer as a refractive index and bio-chemical sensor, Optics Express vol. 22 / Issue 22, pp. 26803-26813, Nov. 2014. [cited by applicant]
Prieto, F et al, An integrated optical interferometric nanodevice based on silicon technology for biosensor applications, Nanotechnology vol. 14 / Issue 8 pp. 907-912, Jul. 2003. [cited by applicant]
Yursever G et al, Photonic integrated Mach-Zehnder interferometer with an on-chip reference arm for optical coherence tomography, Biomed Opt Express, vol. 5/Issue 4, pp. 1050-1061, Apr. 2014. [cited by applicant]