Glycopeptide derivatives for use in the treatment and/or prevention and/or attenuation of fibrosis diseases
The present invention relates to a compound of the following formula (I), as well as to a pharmaceutical composition comprising at least one compound of following formula (I) and at least one pharmaceutically acceptable excipient, for use in the treatment and/or prevention and/or attenuation of fibrosis diseases, in particular excessive scars such as keloids or hypertrophic scars.
1. A method of treating and/or preventing and/or attenuating a fibrosis disease, comprising the administration to a person in need thereof of an effective amount of a compound of following formula (I):
or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
in which:
n represents an integer from 1 to 6,
m represents 0 or 1,
p represents 0 or 1
R represents H, F, CH 3 , CH 2 F, or CH 2 OH,
R 1 , R 2 and R 3 represent, independently from one another, H, F, or OH,
R 4 represents a hydrogen, a halogen, or OH, and
R 6 and R 7 represent, independently from each other, a hydrogen, a (C 1 -C 6 )alkyl, an aryl, or an aryl-(C 1 -C 6 )alkyl.
2. The method according to claim 1 , wherein the fibrosis disease is excessive scars.
3. The method according to claim 2 , wherein the excessive scars are keloids or hypertrophic scars.
4. The method according to claim 1 , wherein the compound of formula (I) has one of the following formulas (Ia), (Ib), (Ic):
5. The method according to claim 1 , wherein n represents an integer from 2 to 6.
6. The method according to claim 1 , wherein R represents a CH 2 OH group.
7. The method according to claim 1 , wherein R 1 , R 2 and R 3 each represent a OH group.
8. The method according to claim 1 , wherein R 4 represents a OH group.
9. The method according to claim 1 , wherein R 6 and R 7 represent, independently from each other, a (C 1 -C 6 )alkyl, an aryl or an aryl-(C 1 -C 6 )alkyl.
10. The method according to claim 1 , wherein the compound of formula (I) is chosen among the following compounds:
and the salts and/or solvates thereof.
11. A method of treating and/or preventing and/or attenuating a fibrosis disease, comprising the administration to a person in need thereof of an effective amount of a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and at least one compound of following formula (I):
or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
in which:
n represents an integer from 1 to 6,
m represents 0 or 1,
p represents 0 or 1
R represents H, F, CH 3 , CH 2 F, or CH 2 OH,
R 1 , R 2 and R 3 represent, independently from one another, H, F, or OH,
R 4 represents a hydrogen, a halogen, or OH, and
R 6 and R 7 represent, independently from each other, a hydrogen, a (C 1 -C 6 )alkyl, an aryl, or an aryl-(C 1 -C 6 )alkyl.
12. The method according to claim 11 , wherein the fibrosis disease is excessive scars.
13. The method according to claim 12 , wherein the excessive scars are keloids or hypertrophic scars.
14. The method according to claim 11 , wherein n represents an integer from 2 to 6; R represents a CH 2 OH group; R 1 , R 2 and R 3 each represent a OH group; R 4 represents a OH group; and R 6 and R 7 represent, independently from each other, a (C 1 -C 6 )alkyl, an aryl or an aryl-(C 1 -C 6 )alkyl.
15. The method according to claim 11 , wherein the compound of formula (I) is chosen among the following compounds:
and the salts and/or solvates thereof.
16. The method according to claim 11 , wherein the pharmaceutical composition is administered topically in combination with or after a laser or surgical treatment.
17. A dressing comprising a pad, compress or sponge impregnated with a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and at least one compound of following formula (I):
or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
in which:
n represents an integer from 1 to 6,
m represents 0 or 1,
p represents 0 or 1
R represents H, F, CH 3 , CH 2 F, or CH 2 OH,
R 1 , R 2 and R 3 represent, independently from one another, H, F, or OH,
R 4 represents a hydrogen, a halogen, or OH, and
R 6 and R 7 represent, independently from each other, a hydrogen, a (C 1 -C 6 )alkyl, an aryl, or an aryl-(C 1 -C 6 )alkyl.
18. The dressing according to claim 17 , wherein n represents an integer from 2 to 6; R represents a CH 2 OH group; R 1 , R 2 and R 3 each represent a OH group; R 4 represents a OH group; and R 6 and R 7 represent, independently from each other, a (C 1 -C 6 )alkyl, an aryl or an aryl-(C 1 -C 6 )alkyl.
19. The dressing according to claim 17 , wherein the compound of formula (I) is chosen among the following compounds:
and the salts and/or solvates thereof.
20. A method of treating and/or preventing and/or attenuating a fibrosis disease, comprising the application to a person in need thereof of a dressing according to claim 17 .
21. The method according to claim 20 , wherein the dressing is applied in combination with or after a laser or surgical treatment.