Method of reducing chemotherapy-induced neutropenia
Disclosed herein are plinabulin and the use for reducing neutropenia. Some embodiments relate to reducing the docetaxel induced neutropenia using plinabulin.
1. A method of treating docetaxel-induced neutropenia in a subject, comprising administering a single dose of plinabulin in a 21-day docetaxel treatment cycle and administering one or more G-CSF drugs.
2. The method of claim 1 , wherein the amount of plinabulin in the single dose is greater than 1 mg/m 2 and less than 40 mg/m2.
3. The method of claim 1 , wherein the plinabulin is administered less than 1 hour after the administration of docetaxel.
4. The method of claim 1 , wherein the plinabulin is administered 10 minutes to 40 minutes after the administration of docetaxel.
5. A method of treating a Docetaxel, Doxorubicin, and Cyclophosphamide (TAC) or Docetaxel and Cyclophosphamide (TC) chemotherapy-induced neutropenia in a subject, comprising administering a single dose of plinabulin in a 21-day treatment cycle and administering one or more G-CSF drugs.
6. The method of claim 5 , wherein the amount of plinabulin in the single dose is greater than 1 mg/m2 and less than 40 mg/m2.
7. The method of claim 5 , wherein the plinabulin is administered less than 1 hour after the administration of the TAC or TC chemotherapy.
8. The method of claim 1 , wherein the neutropenia is a grade 3 or 4 neutropenia.
9. The method of claim 1 , comprising reducing an incidence of grade 4 neutropenia by at least 5%.
10. The method of claim 1 , comprising reducing a duration of grade 4 neutropenia by at least 2 times.
11. A method of treating a chemotherapy induced neutropenia, comprising administering a single dose of plinabulin in a chemotherapy treatment cycle within 2 hours after the administration of the chemotherapy and administering one or more G-CSF drugs, wherein the dose of the G-CSF drug is in the range of 1 mg to 10 mg.
12. The method of claim 11 , wherein the G-CSF drug is pegfilgrastim.
13. The method of claim 11 , comprising administering the GCSF drug at least 24 hours after the administration of the chemotherapy.
14. The method of claim 11 , comprising administering a single dose of plinabulin in a 21-day treatment cycle.
15. The method of claim 11 , comprising administering plinabulin at a dose in the range of 1 mg/m 2 to 50 mg/m2.
16. The method of claim 1 , wherein the patient has an advanced or metastatic breast cancer, early breast cancer, non-small cell lung cancer, or refractory metastatic prostate cancer.
17. The method of claim 1 , wherein administering one or more G-CSF drugs is administered in a dose in a range from of 3 mg to 6 mg.
18. The method of claim 5 , wherein administering one or more G-CSF drug is administered in a dose in a range from of 3 mg to 6 mg.
19. The method of claim 11 , wherein the dose of the G-CSF drug is in a range from of 3 mg to 6 mg.