Compositions and methods for the treatment of hypercholesterolemia
Provided herein are, inter alia, compositions and methods for the treatment of hypercholesterolemia. The compositions include double-stranded and single-stranded RNAs capable of repressing IncRNA and concomitantly increasing LDLR activation. The compositions are useful for activating LDLR in liver cells.
1. A method of treating hypercholesterolemia, said method comprising administering to a subject in need thereof an effective amount of a ribonucleic acid compound,
said ribonucleic acid compound comprising an RNA sequence having at least 95% sequence identity to the complement of at least 15 consecutive nucleotides of nucleotides 1-147 of SEQ ID NO:1, wherein said RNA sequence is capable of hybridizing to nucleotides 27-47 of SEQ ID NO:1; or
said ribonucleic acid compound comprising an RNA sequence having at least 95% sequence identity to the complement of at least 15 consecutive nucleotides of nucleotides 541-631 of SEQ ID NO:2, wherein said RNA sequence is capable of hybridizing to nucleotides 582-602 of SEQ ID NO:2.
2. The method of claim 1 , wherein said RNA sequence is SEQ ID NO:12.
3. The method of claim 1 , wherein said RNA sequence is SEQ ID NO:18.