TRIPLET COMBINATION FORMULATIONS AND METHODS FOR TREATING OR REDUCING THE RISK OF CARDIOVASCULAR DISEASE
Disclosed herein are compositions comprising ETC-1002; Ezetimibe; a statin; and one or more pharmaceutical excipients or carriers. Also disclosed herein are methods for using said composition. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia and/or dyslipidemias in a subject.
1 .- 40 . (canceled)
41 . A pharmaceutical composition comprising:
ETC-1002;
Ezetimibe;
a statin; and
one or more pharmaceutically acceptable excipients or carriers.
42 . The pharmaceutical composition of claim 41 , wherein the amount of ETC-1002 is 180 or 120 mg.
43 . The pharmaceutical composition of claim 41 , wherein the amount of ETC-1002 is between 40 mg to 90 mg.
44 . The pharmaceutical composition of claim 41 , wherein the amount of Ezetimibe is 10 mg.
45 . The pharmaceutical composition of claim 41 , wherein the amount of the statin is between 1 mg to 80 mg.
46 . The pharmaceutical composition of claim 41 , wherein the statin is selected from the group consisting of: atorvastatin, simvastatin, fluvastatin, rosuvastatin, and pitavastatin.
47 . The pharmaceutical composition of claim 41 , wherein the statin is atorvastatin.
48 . The pharmaceutical composition of claim 47 , wherein the amount of atorvastatin is between 10 and 80 mg.
49 . The pharmaceutical composition of claim 41 , wherein the statin is simvastatin.
50 . The pharmaceutical composition of claim 49 , wherein the amount of simvastatin is between 10 and 40 mg.
51 . The pharmaceutical composition of claim 41 , wherein the statin is fluvastatin.
52 . The pharmaceutical composition of claim 51 , wherein the amount of fluvastatin between 20 and 80 mg.
53 . The pharmaceutical composition of claim 41 , wherein the statin is rosuvastatin.
54 . The pharmaceutical composition of claim 53 , wherein the amount of rosuvastatin is between 5 and 40 mg.
55 . The pharmaceutical composition of claim 41 , wherein the statin is pitavastatin.
56 . The pharmaceutical composition of claim 55 , wherein the amount of pitavastatin is between 1 and 4 mg.
57 .- 61 . (canceled)