Implantable electrode with dexamethasone coating

1. A method of forming an implantable electrode having electrode contacts on an electrode carrier having a coating, the method comprising:

providing a solution of silicone and dexamethasone dissolved in a solvent;

applying the solution to the electrode carrier or to a substrate; and

subjecting the solution to a two-step heat treatment process that includes a first heat treatment between 50° C. and 90° C. for about 1 to 3 hours and a second heat treatment at an elevated temperature between about 90° C. and 140° C. for about 2 hours in order to form the coating.

2. The method of claim 1 , wherein the coating is applied directly on the electrode carrier.

3. The method of claim 1 , wherein the coating is applied onto the substrate, the method further comprising transferring the coating from the substrate to the electrode carrier.

4. The method of claim 1 , wherein the coating is applied onto the substrate, the method further comprising fixing the coated substrate to the electrode carrier.

5. The method of claim 1 , wherein the solution is applied using non-contact micro dispensing systems or contact dispensing systems.

6. The method of claim 5 , wherein the non-contact micro dispensing systems include pipe jet dispensing systems, jet-forming dispensing systems, dynamic drop dispensing systems, or combinations thereof.

7. The method of claim 1 , wherein the coating is applied to the electrode carrier or to the substrate in the shape of rings, lines, spots, or combinations thereof and applied between at least two electrode contacts.

8. The method of claim 1 , wherein the solution is formed by dissolving silicone and dexamethasone in the solvent and adding a non-solvent to the solvent, the non-solvent miscible with the silicone, the dexamethasone having a solubility in the non-solvent of below about 5 mg/ml.

9. The method of claim 8 , wherein the non-solvent is added to the solvent to form a solvent mixture before dissolving the silicone and the dexamethasone in the solvent.

10. The method of claim 9 , wherein the dexamethasone is added to the solvent mixture and then the silicone is added to the solvent mixture.

11. The method of claim 8 , wherein the non-solvent is added to the solvent after dissolving the silicone and the dexamethasone in the solvent.

12. The method of claim 8 , wherein the non-solvent is added in an amount of 10% by volume below a saturation of the dexamethasone in the solution.

13. The method of claim 8 , wherein the non-solvent is added in an amount of 5% by volume below a saturation of the dexamethasone in the solution.

14. The method of claim 8 , wherein the non-solvent includes unsubstituted or substituted aliphatic, cycloaliphatic or aromatic hydrocarbons.

15. The method of claim 14 , wherein the non-solvent includes n-hexane or isomers therefrom, n-pentane or isomers therefrom, cyclopentane, n-heptane or isomers therefrom, n-octane or isomers therefrom, n-nonane or isomers therefrom, n-decane or isomers therefrom, n-dodecane or isomers therefrom, benzene, toluene, xylene or combinations thereof.

16. The method of claim 8 , wherein the non-solvent is n-hexane and the solvent is tetrahydrofurane, and the ratio of tetrahydrofurane to n-hexane by volume is about 77/23 in the solution.

17. The method of claim 8 , wherein the dexamethasone solubility in the non-solvent is below about 1 mg/ml.

18. The method of claim 1 , wherein total solid concentration is between about 6% by weight to about 10% by weight in the solution.

19. The method of claim 1 , wherein concentration of the dexamethasone in the coating is between about 10% by weight to about 20% by weight of the coating.

20. The method of claim 1 , wherein the solvent includes tetrahydrofurane.

21. An implantable electrode formed according to the method of claim 1 .