Fluorescent probes
The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.
1. A compound of Formula III:
or a salt thereof, wherein
is a single or double bond;
X b is O;
Y b is O;
L 1b is a bond;
L 3b is (CR z ) u ;
u is 2;
L 2b is (CH) 3 ;
Z b is N;
ring B is selected from C 6-10 aryl and 5-10 membered heteroaryl;
ring A b is selected from C 6-10 aryl and 5-10 membered heteroaryl;
each R z is independently selected from H and C 1-6 alkyl;
each R 8b is independently NR c1 R d1 ;
each R 10b is independently C 1-6 alkyl;
R 11b and R 12b are each C 1-6 alkyl;
R c1 and R d1 are each independently selected from C 1-6 alkyl;
v is 1, 2, or 3; and
w is 1, 2, or 3.
2. The compound of claim 1 , wherein ring A b is C 6-10 aryl.
3. The compound of claim 1 , wherein the compound is
or a salt thereof.