Biometric method
View Patent ↗A biometric method includes: a step ( 1 ) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, the radical molecule C having an unpaired electron; and a step ( 2 ) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals. The step ( 2 ) is carried out in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F. The biometric method makes it possible to measure low-sensitivity magnetic resonance nucleus such as 13 C, 15 N, and 31 P, which are important nuclides present in organism, with performance equal to or over that of a high-field MRI device.
1. A biometric method including:
a step (1) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, the radical molecule C having an unpaired electron; and
a step (2) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals,
the step (2) being carried out in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F.
2. The biometric method as set forth in claim 1 , wherein the magnetic resonance nucleus comprises one of 13 C, 14 N, 15 N, and 31 P.
3. The biometric method as set forth in claim 1 , wherein the step (2) is carried out in a magnetic field having an intensity equal to or smaller than 50 mT.
4. The biometric method as set forth in claim 1 , wherein the step (2) is carried out in a magnetic field having a constant intensity.
5. The biometric method as set forth in claim 1 , wherein one of the target molecule A and the target molecule B includes two or more magnetic resonance nuclei having a gyromagnetic ratio smaller than the same of 19 F.
6. The biometric method as set forth in claim 1 , wherein one of the target molecule A and the target molecule B has accumulation characteristics to tumor.
7. The biometric method as set forth in claim 1 , wherein one of the target molecule A and the target molecule B comprises glucose derivative.
8. A biometric apparatus including:
a first device for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, the radical molecule C having an unpaired electron; and
a second device for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals,
the second device measuring the nuclear magnetic resonance signals in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F.
9. The biometric apparatus as set forth in claim 8 , wherein the magnetic resonance nucleus comprises one of 13 C, 14 N, 15 N, and 31 P.
10. The biometric apparatus as set forth in claim 8 , wherein the second device measures the nuclear magnetic resonance signals in a magnetic field having an intensity equal to or smaller than 50 mT.
11. The biometric apparatus as set forth in claim 8 , wherein the second device measures the nuclear magnetic resonance signals in a magnetic field having a constant intensity.
12. The biometric apparatus as set forth in claim 8 , wherein one of the target molecule A and the target molecule B includes two or more magnetic resonance nuclei having a gyromagnetic ratio smaller than the same of 19 F.
13. The biometric apparatus as set forth in claim 8 , wherein one of the target molecule A and the target molecule B has accumulation characteristics to tumor.
14. The biometric apparatus as set forth in claim 8 , wherein one of the target molecule A and the target molecule B comprises glucose derivative.
15. A non-transitory recording medium readable by a computer, storing a program therein for causing a computer to carry out a biometric method in a biometric apparatus, the method including:
a step (1) for administering, to a target organism from the outside thereof, one of (i) a target molecule A having both an unpaired electron and a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, and (ii) a target molecule B and a radical molecule C, the target molecule B having no unpaired electron, and further having a magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F, the radical molecule C having an unpaired electron; and
a step (2) for causing electron spin resonance in the unpaired electron of the target molecule A or the radical molecule C by irradiating electromagnetic waves to the target organism, subsequently triggering nuclear magnetic resonance in the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F in one of the target molecule A and the target molecule B, and further, measuring nuclear magnetic resonance signals,
the step (2) being carried out in a magnetic field having such an intensity that the nuclear magnetic resonance signals of the magnetic resonance nucleus in one of the target molecule A and the target molecule B are degenerated, the magnetic resonance nucleus having a gyromagnetic ratio smaller than the same of 19 F.
16. The non-transitory recording medium as set forth in claim 15 , wherein the step (2) is carried out in a magnetic field having an intensity equal to or smaller than 50 mT.
17. The non-transitory recording medium as set forth in claim 15 , wherein the step (2) is carried out in a magnetic field having a constant intensity.