IP Library Granted Patent US 11,684,648
Granted Patent B2
US 11,684,648 · App. 16/492,473 · Granted Jun 27, 2023

Synergistic herbal compositions for testosterone boosting

Inventors: Ganga Raju Gokaraju (Vijaywada, IN); Rama Raju Gokaraju (Vijayawada, IN); Trimurtulu Golakoti (Vijayawada, IN); Kiran Bhupathiraju (Vijayawada, IN); Venkata Kanaka Ranga Raju Gokaraju (Vijayawada, IN); Krishanu Senguptha (Vijayawada, IN); Venkata Krishna Raju Alluri (Vijayawada, IN); Venkateswarlu Somepalli (Vijayawada, IN)
Assignee: LAILA NUTRACEUTICALS
A61K36/54A61K36/22A61K36/31A61K36/71A61K36/8962A61P5/24A61K36/48A61K2300/00
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Quick Facts
Patent No.
US 11,684,648
App. No.
16/492,473
Granted
Jun 27, 2023
Kind
B2
Abstract

Synergistic herbal compositions for Testosterone boosting comprising at least two ingredients selected from the extracts, fractions or pure phytochemicals derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The present invention also describes a synergistic composition comprising at least one testosterone booster ingredient selected from the extracts, fractions or pure phytochemical derived from Punica granatum, Cinnamomum zeylanicum, Nigella sativa, Brassica nigra and Mangifera indica and at least one aromatase inhibitor ingredient selected from the extracts, fractions or pure phytochemicals derived from Allium cepa, Tamarindus indica and Cinnamomum tamala for improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans. The invention further provides methods of improving testosterone levels and alleviating symptoms associated with low levels of testosterone hormone in humans.

Claims (27)

1. A synergistic herbal composition comprising:

a first testosterone booster ingredient selected from the group consisting of water, aqueous alcohol, or alcohol extracts of Punica granatum fruit rind, Cinnamomum zeylanicum bark, Nigella sativa seeds and/or fruit, Brassica nigra seeds, and Mangifera indica stem bark or leaves; and

at least one second testosterone booster ingredient selected from the group consisting of water, aqueous alcohol, or alcohol extracts of Punica granatum fruit rind, Cinnamomum zeylanicum bark, Nigella sativa seeds and/or fruit, Brassica nigra seeds, and Mangifera indica stem bark or leaves, wherein:

the second testosterone booster ingredient does not include the first testosterone booster ingredient; and

the first and second testosterone booster ingredients are used in a ratio of from 1:3 to 3:1 by weight.

2. The synergistic herbal composition as claimed in claim 1 , wherein the testosterone booster ingredients are present in an amount effective to treat low levels of testosterone.

3. The synergistic herbal composition as claimed in claim 1 , wherein the synergistic composition further comprise at least one additional component selected from the group consisting of biological agent(s); pharmaceutically acceptable active ingredients, vitamins, minerals; pharmaceutically or nutraceutically or dietically acceptable excipients, carriers, and diluents.

4. The synergistic composition as claimed in claim 3 , wherein the pharmaceutically or nutraceutically or dietically acceptable excipients, carriers and diluents are selected from the group consisting of glucose, fructose, sucrose, maltose, yellow dextrin, white dextrin, aerosil, microcrystalline cellulose, neusilin, calcium stearate, magnesium stearate, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-alpha-tocopherol, glycerin, propylene glycol, glycerin fatty ester, poly glycerin fatty ester, sucrose fatty ester, sorbitan fatty ester, propylene glycol fatty ester, acacia, carrageenan, casein, gelatin, pectin, agar, vitamin B group, nicotinamide, calcium pantothenate, amino acids, proteins, calcium salts, pigments, flavors, preservatives, distilled water, saline, aqueous glucose solution, alcohol, propylene glycol and polyethylene glycol, animal and vegetable oils, white soft paraffin, paraffin, flavorants, colourants and wax.

5. The synergistic composition as claimed in claim 3 , wherein the composition can be formulated into a dosage form selected from the group consisting of a dry powder form, a liquid form, a beverage, a food product, a dietary supplement, a tablet, a capsule, a soft chewable tablet, and a gummy bear.

6. The synergistic composition as claimed in claim 3 , wherein the composition can be formulated into a food product, the food product being a solid food, a chocolate bar, a nutritional bar, a semisolid food, a cream, a jam, a gel, a beverage, a lactic acid bacteria beverage, a drop, a candy, a chewing gum, a gummy candy, a yoghurt, an ice cream, a pudding, a soft adzuki bean jelly, a jelly, a cookie, a tea, a soft drink, a juice, a milk, a coffee, a cereal, or a snack bar.

7. The synergistic composition as claimed in claim 1 , wherein each of the extracts is obtained from at least one plant part selected from the group consisting of leaves, stems, tender stems, tender twigs, aerial parts, whole fruit, fruit rind, seed, root, bark, bulb, hardwood, a whole plant, and mixtures thereof.

8. The synergistic herbal composition as claimed in claim 1 , wherein each of the extracts is produced using at least one solvent selected from the group consisting of C1-C5 alcohols; water; and mixtures thereof.

9. A method of increasing the testosterone levels, or treating/alleviating low levels of testosterone in a human subject, wherein the method comprises treating the human subject with an effective dose of the synergistic herbal composition of claim 1 .

10. The synergistic herbal composition as claimed in claim 1 , further comprising an aromatase inhibitor ingredient comprising at least one extract of an aromatase inhibitor herb selected from the group consisting of Allium cepa, Tamarindus indica , and Cinnamomum tamala.

11. The synergistic herbal composition as claimed in claim 1 , wherein each of the extracts is produced using at least one solvent selected from the group consisting of ethanol, methanol, n-propanol, isopropyl alcohol, water, and mixtures thereof.

12. The synergistic herbal composition as claimed in claim 1 , wherein:

the first testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Punica granatum fruit rind; and

the second testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Cinnamomum zeylanicum bark, Nigella sativa seeds and/or fruit, Brassica nigra seeds, Mangifera indica stem bark, or Mangifera indica leaves.

13. The synergistic herbal composition as claimed in claim 1 , wherein:

the first testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Cinnamomum zeylanicum bark; and

the second testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Nigella sativa seeds and/or fruit, Brassica nigra seeds, Mangifera indica stem bark, or Mangifera indica leaves.

14. The synergistic herbal composition as claimed in claim 1 , wherein:

the first testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Nigella sativa seeds and/or fruit; and

the second testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Brassica nigra seeds, Mangifera indica stem bark, or Mangifera indica leaves.

15. The synergistic herbal composition as claimed in claim 1 , wherein:

the first testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Brassica nigra seeds; and

the second testosterone booster ingredient is a water, aqueous alcohol, or alcohol extract of Mangifera indica stem bark or Mangifera indica leaves.

Assignments (2)
CHANGE OF NAME Recorded Aug 18, 2025
From: LAILA NUTRACEUTICALS
To: LAILA NUTRA PRIVATE LIMITED
Reel/Frame 072508/0229 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2023
From: GOKARAJU, GANGA RAJU; GOKARAJU, RAMA RAJU; GOLAKOTI, TRIMURTULU; BHUPATHIRAJU, KIRAN; GOKARAJU, VENKATA KANAKA RANGA RAJU; SENGUPTHA, KRISHANU; ALLURI, VENKATA KRISHNA RAJU; SOMEPALLI, VENKATESWARLU
To: LAILA NUTRACEUTICALS
Reel/Frame 063508/0646 →
Priority Claims (2)
IN 201741008126 · Mar 8, 2017 · national
IN 201741041318 · Nov 18, 2017 · national
Continuity (1)
Related Publication 20210138014A1 · May 13, 2021