Granted Patent
B2
US 12,303,548 · App. 16/492,903 · Granted May 20, 2025
Complexes for treating sensitivity
Assignee:
The University of Melbourne
A61K38/1709A61K8/21A61K8/24A61K8/64A61K33/06A61K33/16A61K33/24A61K33/42A61K38/00A61P1/02A61Q11/00A61K9/0053A61K2800/58
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Abstract
The present invention relates to improved phosphopeptide stabilised amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complexes and compositions containing those complexes. Methods of making the complexes of the invention and of treatment dental hypersensitivity are also provided. In one embodiment, the invention provides a stannous-associated phosphopeptide (PP) stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex having a stannous ion content of equal to, or greater than, 1 mole of stannous per mole of PP but less than 4 moles of stannous per mole of PP.
Claims (29)
1. A stannous-associated phosphopeptide (PP) stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex, wherein the complex has a stannous ion content of from 1.4 moles of stannous per mole of PP to 2.0 moles of stannous per mole of PP, wherein the phosphopeptide is a casein phosphopeptide.
2. The complex according to claim 1 , wherein the complex has a stannous ion content of about 1.6 moles of stannous per mole of PP.
3. A composition comprising the complex according to claim 1 , and a pharmaceutically acceptable carrier, diluent or excipient.
4. The composition according to claim 3 , wherein the composition is a formulation selected from the group consisting of dentifrices, mouthwashes, mouthrinses, mouth sprays, varnishes, dental cements, troches, chewing gums, dental pastes, gingival massage creams, gargle tablets, and dairy products.
5. The composition according to claim 4 , wherein the composition is a dentifrice selected from the group consisting of toothpastes, toothpowders and liquid dentifrices.
6. A method for treating or preventing dentinal sensitivity in an individual in need thereof having exposed dentine, comprising administering to the individual the complex according to claim 1 , thereby treating or preventing dentinal sensitivity in the individual.
7. The method according to claim 6 , wherein the individual is suffering from dentinal sensitivity.
8. The method according to claim 7 , wherein the dentinal sensitivity is hypersensitivity.
9. The method according to claim 6 , further comprising identifying exposed dentinal tubules in the individual.
10. The method according to claim 9 , wherein the individual is identified as having dentinal tubules with openings greater than 1.0 μm in diameter.
11. The method according to claim 9 , wherein the individual is identified as having dentinal tubules with openings greater than 2.0 μm in diameter.
12. The method according to claim 6 , wherein the exposed dentine contains dentinal tubules with openings greater than 1 μm in diameter.
13. A method or process for forming a stannous-associated PP stabilized ACP complex according to claim 1 , comprising:
(i) obtaining a solution comprising at least one phosphopeptide and;
(ii) admixing solutions comprising calcium ions and phosphate ions, while maintaining the pH at about 7.3 or below; and
(iii) admixing a stannous compound in an amount to yield a complex having a stannous ion content of from 1.4 moles of stannous per mole of PP to 2.0 moles of stannous per mole of PP; or
(a) providing a solution of phosphopeptide stabilized ACP; and
(b) admixing a stannous compound in an amount to yield a complex having a stannous ion content of from 1.4 moles of stannous per mole of PP to 2.0 moles of stannous per mole of PP, wherein the phosphopeptide is a casein phosphopeptide.
14. The method according to claim 13 , wherein method does not involve addition of any base or acid.
15. The method according to claim 13 , wherein no hydroxide ions are added separately to the solution comprising calcium ions, phosphate ions or stannous compound.
16. A method for forming a stannous-associated PP stabilized ACFP complex according to claim 1 , comprising:
(i) obtaining a solution comprising at least one phosphopeptide and;
(ii) admixing solutions comprising calcium ions, phosphate ions and fluoride ions, while maintaining the pH at about 7.3 or below; and
(iii) admixing a stannous compound in an amount to yield a complex having a stannous ion content of from 1.4 moles of stannous per mole of PP to 2.0 moles of stannous per mole of PP; or
(a) providing a solution of phosphopeptide stabilized ACFP; and
(b) admixing a stannous compound in an amount to yield a complex having a stannous ion content of from 1.4 moles of stannous per mole of PP to 2.0 moles of stannous per mole of PP, wherein the phosphopeptide is a casein phosphopeptide.
17. The complex according to claim 1 , wherein the complex has a stannous ion content of 1.4 moles of stannous per mole of PP.
18. The complex according to claim 1 , wherein the complex has a stannous ion content of 1.8 moles of stannous per mole of PP.
19. The complex according to claim 1 , wherein the complex has a stannous ion content of 2.0 moles of stannous per mole of PP.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 26, 2020
From: REYNOLDS, ERIC CHARLES
To: THE UNIVERSITY OF MELBOURNE
Reel/Frame 051941/0101 →
Priority Claims (1)
AU 2017900892
· Mar 14, 2017
· national
Continuity (1)
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