IP Library Granted Patent US 11,020,488
Granted Patent B2
US 11,020,488 · App. 16/493,690 · Granted Jun 1, 2021

Pyrroloquinolin compounds and methods of using same

Inventors: Phillip Crews (Santa Cruz, CA); Frederick A. Valeriote (Washington, MI); Sheng Lin (Beijing, CN); Erin P. McCauley (Santa Cruz, CA); Nicholas Lorig-Roach (Santa Cruz, CA); Karen Tenney (Santa Cruz, CA)
Assignees: The Regents of the University of California; Henry Ford Health System
A61K47/6803A61K31/437A61P35/00C07D471/06
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Quick Facts
Patent No.
US 11,020,488
App. No.
16/493,690
Granted
Jun 1, 2021
Kind
B2
Abstract

Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.

Claims (4)

1. A compound selected from the group consisting of:

2. A pharmaceutical composition, comprising:

the compound of claim 1 ; and

a pharmaceutically acceptable carrier.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2020
From: CREWS, PHILLIP; LIN, SHENG; MCCAULEY, ERIN P.; LORIG-ROACH, NICHOLAS; TENNEY, KAREN
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 053908/0186 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2020
From: VALERIOTE, FREDERICK A.
To: HENRY FORD HEALTH SYSTEM
Reel/Frame 053908/0222 →
Continuity (2)
Provisional Application 62471261 · Mar 14, 2017
Related Publication 20200129631A1 · Apr 30, 2020