Breath-condensate analyser
An analyser for collecting and analysing a breath condensate is disclosed. The analyser comprises a housing and a cartridge device ( 10 ). The device comprises a condensation zone ( 12 ) to condense exhaled breath from a subject and cooling means operably connected to the condensation zone ( 12 ). The device includes further discrete regions ( 13 ) for detection of analyte and measurement of analyte. The condensation zone ( 12 ) has a fluid exit connecting the condensation zone ( 12 ) to the discrete regions ( 13 ). The analyser includes a mouthpiece which is provided with a plurality of chambers configured to cause a change of 90° in the direction of the exhaled breath in order to trap saliva aerosols.
1. An analyser for collecting and analysing a breath condensate, the analyser comprising a housing, the housing having a cooling means and, further, retaining a cartridge device comprising a condensation zone to condense exhaled breath from a subject, the cooling means being in cooling relationship with the condensation zone, the cartridge including one or more further discrete regions for detection of an analyte and measurement of the analyte, the cartridge further comprising a fluid path connecting the condensation zone to the or each discrete region, the housing including a mouth-piece having an entry port to enable a user to breathe into the mouth-piece, the mouth-piece comprising one or more fluid passages to direct breath entering the mouth-piece into the condensation zone, the mouth-piece further comprising an exit valve, and a plurality of chambers interposed between the entry port and exit valve to direct fluid flow from the entry port to the exit valve, the chambers being so configured to cause a change of 90 in the direction of fluid flow, wherein at least two chambers are separated by a one-way valve.
2. The analyser according to claim 1 , wherein the cartridge is removably attachable to the housing.
3. The analyser according to claim 1 , wherein the housing comprises a heating means to heat a reaction zone which itself forms part of the cartridge.
4. The analyser according to claim 3 , wherein the heating means is arranged in the housing or as part of the cartridge.
5. The analyser according to claim 4 , wherein there is an electrical connection between the housing and the cartridge.
6. The analyser according to claim 1 , wherein the housing comprises a series of baffles to remove saliva aerosol from a vapour sample.
7. The analyser according to claim 6 , wherein one or more baffles is provided in the mouth-piece.
8. The analyser according to claim 7 , wherein a single baffle is provided in each of the mouth-piece, housing and the cartridge.
9. The analyser according to claim 1 , wherein the housing comprises a valve system to provide at least two flow paths through the cartridge.
10. The analyser according to claim 1 , wherein the housing and/or the cartridge comprises a flow rate sensor for measuring breath flow rate.
11. The analyser according to claim 1 , wherein the housing and/or the cartridge comprises a carbon dioxide sensor.
12. The analyser according to claim 1 , wherein the housing and/or the cartridge comprises one or more humidity/relative humidity sensors.
13. The analyser according to claim 1 , wherein the housing and/or the cartridge comprises a pressure sensor for measuring breath pressure during exhalation or inhalation.
14. The analyser according to claim 1 , wherein the housing and/or the cartridge comprises a temperature sensor for measuring breath temperature.
15. The analyser according to claim 1 , wherein the housing comprises an electronic interface for providing information from one or more sensors to an external device and/or for receiving electrical energy from an external source.
16. The analyser according to claim 1 , wherein the housing comprises a data processing unit.
17. The analyser according to claim 1 , wherein the housing comprises an electronic interface for a removable data storage means, or via wire or wireless data transmission.
18. The analyser according to claim 1 , wherein the housing comprises an audio output.