Glucose responsive insulin comprising a tri-valent sugar cluster for treatment of diabetes
An insulin conjugate comprising or consisting of a tri-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
1. A conjugate selected from the group consisting of
2. A composition comprising a conjugate of claim 1 and a pharmaceutically acceptable carrier.
3. A method for treating diabetes comprising administering to an individual in need thereof a therapeutically effective amount of the conjugate of claim 1 to treat the diabetes.
4. The method of claim 3 , wherein the diabetes is Type I diabetes, Type II diabetes, or gestational diabetes.
5. A method for treating diabetes comprising administering to an individual in need thereof a therapeutically effective amount of the composition of claim 2 to treat the diabetes.
6. The method of claim 5 , wherein the diabetes is Type I diabetes, Type II diabetes, or gestational diabetes.