Inhibitors
The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.
1. A compound of formula I:
A-B-D-E (I)
or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein:
A is
B is alkyl;
D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted with one or more substituents; and
E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted with one or more substituents.
2. The compound according to claim 1 , wherein B is selected from methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, and octyl.
3. The compound according to claim 1 , wherein D is a group selected from
wherein
R is absent or is hydrogen;
R 2 is hydrogen, alkyl or cycloalkyl;
Y 1 , Y 2 , Y 3 and Y 4 are independently selected from CH, N, S and O;
Y 4 is optionally substituted with alkyl or halogen.
4. The compound according to claim 1 , wherein E is
wherein
Y 5 is C and Y 6 —Y 10 are independently selected from CH, N or O, and
R 3 , R 4 , R 5 , R 6 , and R 7 are independently selected from hydrogen, halogen, alkyl, O-alkyl, O-phenyl and O-cycloalkyl.
5. The compound according to claim 1 , which is a compound of formula (XVa) or formula (XVb):
wherein
Y 1 to Y 4 and Y 6 to Y 10 are independently selected from CH, N, S and O;
Y 5 is C;
Y 4 is optionally substituted with alkyl or halogen;
R 5 is selected from halogen, alkyl, O-alkyl, O-phenyl and O-cycloalkyl; and
R 6 is selected from hydrogen, alkyl and O-alkyl.
6. The compound according to claim 1 , which is a compound of formula (XVI):
wherein
R 5 is selected from halogen, alkyl and O-alkyl; and
R 6 is selected from hydrogen, alkyl and O-alkyl.
7. The compound according to claim 1 , which is a compound of formula (XVII):
wherein
R 2 is selected from alkyl and cycloalkyl;
R 5 is selected from halogen, alkyl and O-alkyl; and
R 6 is selected from hydrogen, alkyl and O-alkyl.
8. The compound according to claim 1 , which is a compound selected from:
N-[(1H-1,3-benzodiazol-5-yl)methyl]-4′-fluoro-[1,1′-biphenyl]-2-amine;
N-[(1H-1,3-benzodiazol-5-yl)methyl]-3′,4′-dimethoxy-[1,1′-biphenyl]-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-methoxyphenyl)aniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-methoxyphenyl)pyridin-3-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(4-methoxyphenyl)pyridin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(4-methoxyphenyl)pyridin-4-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-4-(4-methoxyphenyl)pyridin-3-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-5-(4-methoxyphenyl)pyrimidin-4-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(4-methoxyphenyl)pyrazin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(3,4-dimethoxyphenyl)pyridin-4-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(3,4-dimethoxyphenyl)pyridin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(3,4-dimethoxyphenyl)pyrazin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-fluorophenyl)pyridin-3-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(4-fluorophenyl)pyridin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-(4-fluorophenyl)pyrazin-2-amine;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-phenoxyphenyl)aniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-[4-(cyclohexyloxy)phenyl]aniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-propoxyphenyl)aniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-244-(propan-2-yloxy)phenyl]aniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-methoxyphenyl)-3-methylaniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(3,4-dimethoxyphenyl)-3-methylaniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(4-chlorophenyl)-3-fluoroaniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(3,4-dimethoxyphenyl)-3-fluoroaniline;
N-(1H-1,3-benzodiazol-5-ylmethyl)-3-fluoro-2-(4-fluorophenyl)aniline;
N-[(1H-1,3-benzodiazol-5-yl)methyl]-4-fluorobenzene-1-sulfonamide; and
[(1H-1,3-benzodiazol-5-yl)methyl][(4-fluorophenyl)(methyl)oxo-λω-sulfanylidene]amine;
or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers.
9. N-(1H-1,3-benzodiazol-5-ylmethyl)-2-(3,4-dimethoxyphenyl)-3-fluoroaniline.
10. A pharmaceutical composition comprising a compound according to claim 1 together with a therapeutically acceptable diluent.