Methods and compositions for modulating β-amyloid/α7-nAChR interactions
Methods of modulating the interaction between β-amyloid and α7-nAChR are provided. Aspects of the methods include administering to the subject an effective amount of a naphthalene derivative active agent. Compositions and kits for practicing the subject methods are also provided. The methods, compositions and kits find use in treating a variety of applications, such as treating a subject for a neurodegenerative disease, e.g., Alzheimer's disease.
1. A method of treating a subject for a neurodegenerative disease, the method comprising:
administering to the subject an effective amount of a compound selected from the group consisting of:
to treat the subject for the neurodegenerative disease.
2. The method according to claim 1 , wherein the neurodegenerative disease is selected from the group consisting of: Alzheimer's disease, Parkinson's disease, frontotemporal dementia, progressive supranuclear palsy, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, multiple sclerosis, multi-system atrophy, glaucoma, ataxias, myotonic dystrophy and dementia.
3. The method according to claim 2 , wherein the neurodegenerative disease is Alzheimer's disease.
4. The method according to claim 1 , wherein the subject is a mammal.
5. The method according to claim 4 , wherein the subject is a human.
6. A pharmaceutical composition comprising:
a) a compound selected from the group consisting of:
and
b) a pharmaceutical delivery vehicle.
7. A kit comprising:
a dose of a compound selected from the group consisting of:
and
a dose of a second active agent having neurodegenerative disease therapeutic activity.