Treating extrapyramtdal syndrome using trapidil
Disclosed herein are methods, pharmaceutical combinations, or kits for the prevention or treatment of extrapyramidal syndromes, for example, dyskinesia, dystonia, akathisia, or drug-induced Parkinsonism, with the administration of a therapeutic effective amount of Trapidil, a derivative, a metabolite, a prodrug, an analog, or a pharmaceutically acceptable salt thereof.
1. A combination therapy method for treating Parkinson's disease in a subject in need thereof, comprising administering to the subject a combination of:
Trapidil, a derivative, a metabolite, or a pharmaceutically acceptable salt thereof; and levodopa;
thereby treating Parkinson's disease in the subject; wherein the derivative of Trapidil is
or 5-piperidino-7-(N-(n-amyl)-N-(beta-hydroxyethyl)-amino)-s-triazolo(1,5-a)pyrimidine)
wherein the metabolite of Trapidil is TP-1
and wherein the Trapidil is administered in a dose of about 50 mg to about 300 mg.
2. The method of claim 1 , wherein the levodopa is formulated with a decarboxylase inhibitor.
3. The method of claim 2 , wherein the decarboxylase inhibitor is comprised of carbidopa or benserazide.
4. The method of claim 1 , wherein the pharmaceutically acceptable salt of Trapidil comprises a salt with hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, oxalic acid, malonic acid, or tartaric acid.
5. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof and the levodopa are administered simultaneously, sequentially, or at an interval period of time.
6. The method of claim 5 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof is administered prior to administration of the levodopa.
7. The method of claim 5 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof is administered after administration of the levodopa.
8. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof and the levodopa are administered as a combined dosage form.
9. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof and the levodopa are each independently formulated for oral administration.
10. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof and the levodopa are each independently formulated for parenteral administration.
11. The method of claim 1 , wherein the Parkinson's disease is manifested as a dyskinesia, dystonia, akathisia, bradykinesia, tremors, or akinesia.
12. The method of claim 1 , wherein the Parkinson's disease is manifested as a dyskinesia.
13. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof potentiate the effect of the levodopa.
14. The method of claim 1 , wherein the Trapidil, the derivative, the metabolite, or the pharmaceutically acceptable salt thereof is used as an adjunctive or adjuvant therapeutic agent.
15. The method of claim 1 , wherein the subject is a human.
16. The method of claim 1 , wherein the dose is from about 50 mg per day to about 1000 mg per day.
17. The method of claim 1 , wherein the dose is from about 50 mg per day to about 600 mg per day.
18. The method of claim 1 , wherein the dose is from about 50 mg per day to about 400 mg per day.
19. The method of claim 1 , wherein the dose is from about 50 mg per day to about 300 mg per day.
20. The method of claim 16 , wherein the dose is administered about 5 times per day.
21. The method of claim 17 , wherein the dose is administered about 4 times per day.
22. The method of claim 18 , wherein the dose is administered about 2 times per day.
23. The method of claim 19 , wherein the dose is administered once per day.