Intravascular treatment catheters
The present invention provides devices and methods for decalcifying an aortic valve. The methods and devices of the present invention break up or obliterate calcific deposits in and around the aortic valve through application or removal of heat energy from the calcific deposits.
1. A method comprising:
advancing a catheter within vasculature of a patient to a treatment site within a body lumen of the patient;
deploying an expandable distal basket from the catheter, wherein the expandable distal basket comprises a plurality of elongate members, and wherein removing the expandable distal basket from the catheter allows the expandable distal basket to transform from a low-profile delivery configuration to an expanded deployed configuration in which one or more elongate members of the plurality of elongate members contact a wall of the body lumen, wherein the plurality of elongate members comprise a plurality of electrodes arranged along the plurality of elongate members, wherein the plurality of electrodes are configured to be positioned in contact with the wall of the body lumen when the distal basket is in the expanded deployed configuration, and wherein at least two of the electrodes are at different longitudinal positions along the distal basket;
delivering energy to generate an electric field to target tissue adjacent the body lumen using the plurality of electrodes; and
delivering a pharmaceutical agent into the body lumen through a plurality of infusion ports or outlets, wherein the plurality of infusion ports or outlets are distributed along at least one elongate member of the plurality of elongate members and are interspersed among and distinct from the plurality of electrodes.
2. The method of claim 1 , wherein the plurality of elongate members are fabricated from shape-memory material.
3. The method of claim 1 , wherein the plurality of elongate members comprise a metal.
4. The method of claim 1 , wherein the plurality of elongate members comprise a plastic.
5. The method of claim 1 , wherein the expandable distal basket is configured to self-expand upon being removed from the catheter.
6. The method of claim 1 , further comprising mechanically actuating the expandable distal basket from the low-profile delivery configuration to the expanded deployed configuration after removing the expandable distal basket from the catheter.
7. The method of claim 1 , wherein the plurality of electrodes are arranged in a staggered configuration along the plurality of elongate members, and wherein delivering the electric field comprises selectively energizing a subset of the plurality of electrodes to produce a selected treatment electric field.
8. The method of claim 1 , wherein delivering energy to generate the electric field comprises delivering a non-pulsed thermal RF electric field.
9. The method of claim 1 , wherein delivering energy to generate the electric field comprises delivering a pulsed electric field.
10. The method of claim 1 , wherein a plurality of electrodes are carried by each elongate member.
11. The method of claim 1 , wherein the plurality of infusion ports or outlets are configured to allow infusion of the pharmaceutical agent before, during, and/or after delivering the electric field.