Immediate release formulations of cannabinoids
Compositions for the immediate release of one or more cannabinoids, in which the compositions comprise a population of particles. Each particle may comprise the one or more cannabinoids and one or more intra-granule excipients. Alternatively, each particle may comprise the one or more cannabinoids and a porous bead core. The composition may be prepared by a method that involves combining the one or more cannabinoids with the one or more intra-granule excipients, and then granulating the combination, such as through fluid bed granulation, shear-induced wet granulation, or spray granulation. The composition may also be prepared by a method that involves mixing the one or more cannabinoids with a population of porous bead cores.
1. A composition for immediate release of one or more cannabinoids, the composition comprising a population of particles, wherein each particle comprises:
(a) the one or more cannabinoids;
(b) one or more intra-granule excipients;
wherein about 80% of the particles is between about 20 μm and about 2000 μm in diameter; and
wherein the composition releases at least about 30% of the one or more cannabinoids over a period of about 30 minutes or less.
2. The composition of claim 1 , wherein the one or more cannabinoids comprises Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), or a combination thereof.
3. The composition of claim 1 , wherein the one or more cannabinoids comprises a combination of THC and CBD.
4. The composition of claim 1 , wherein the one or more intra-granule excipients comprises one or more diluents, one or more binders, one or more fillers, one or more surfactants/emulsifying agents, one or more disintegrants, or a combination thereof.
5. The composition of claim 1 , wherein the one or more intra-granule excipients comprises one or more cellulose derivatives.
6. The composition of claim 5 , wherein the one or more cellulose derivatives is selected from the group consisting of lactose, isomalt, cellulose, starch, cyclodextrin, mannitol, sorbitol, and a combination thereof.
7. The composition of claim 1 , wherein the composition releases about 30% of the one or more cannabinoids over a period of about 30 minutes or less.
8. The composition of claim 1 , wherein about 70% of the particles is between about 100 μm and about 700 μm in diameter.