Granted Patent
B2
US 10,941,137 · App. 16/516,398 · Granted Mar 9, 2021
Difluoromethyl-phenyl triazoles
Inventors:
Janus Schreiber Larsen (Holbæk, DK); Florian Binder (Ingelheim am Rhein, DE); Yunhai Cui (Ingelheim am Rhein, DE); Oliver Hucke (Ingelheim am Rhein, DE); Radoslaw Lipinski (Ingelheim am Rhein, DE); Florian Montel (Ingelheim am Rhein, DE); Markus Ostermeier (Ingelheim am Rhein, DE); Alexandre Perera (Ingelheim am Rhein, DE); Stefan Peters (Ingelheim am Rhein, DE)
Assignee:
Boehringer Ingelheim International GmbH
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Abstract
The present invention relates to difluoromethyl-phenyl triazoles of general formula (I) which are modulators of GABA A receptors containing the α5 subunit, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
Claims (4)
1. A compound selected from the group consisting of
Structure
2. A pharmaceutically acceptable salt of the compound of claim 1 .
3. A compound having the following structure
Assignments (3)
CHANGE OF NAME
Recorded Jan 21, 2021
From: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
To: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Reel/Frame 056981/0690 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 21, 2021
From: BINDER, FLORIAN; CUI, YUNHAI; HUCKE, OLIVER; LIPINSKI, RADOSLAW MICHAL; MONTEL, FLORIAN; PETERS, STEFAN; OSTERMEIER, MARKUS; PERERA, ALEXANDRE
To: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
Reel/Frame 054980/0644 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 21, 2021
From: LARSEN, JANUS SCHREIBER
To: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Reel/Frame 054982/0155 →
Priority Claims (1)
EP 18184716
· Jul 20, 2018
· regional
Continuity (1)