Multi-tyrosine kinase inhibitors derivatives and methods of use
The present invention is directed to multi-tyrosine kinase inhibitor compounds. The present invention is further directed to compositions comprising those compounds. Finally, the present invention is directed to methods of treating eye conditions including, but not limited to, diabetic background retinopathy, diabetic macular edema, diabetic proliferative retinopathy, diabetic macular edema with proliferative retinopathy, proliferative fibrovascular disease, diabetic macular edema with proliferative fibrovascular disease, retinopathy of prematurity, dry macular degeneration, dry macular degeneration with drusen and wet macular degeneration, using compounds and compositions of the invention.
1. A compound of formula (V):
wherein X 1 and X 2 are each, individually a peptide, a protein or absent.
2. A composition comprising a compound of claim 1 and one or more pharmaceutically acceptable excipients.