Devices and methods for endoscopic patch delivery
Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.
1. A method of delivering a patch to a target site of a patient, the method comprising:
introducing an endoscope into a gastrointestinal tract of a patient, wherein the endoscope includes a patch in a folded or crimped configuration, the patch comprising a biocompatible material;
positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from the endoscope;
wherein the target site includes a laceration in tissue following endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or tissue biopsy; or wherein the target site includes an anastomosis;
wherein the endoscope includes a cap coupled to the distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band; and
wherein releasing the patch from the cap includes actuating a wire to cut the flexible band from the cap.
2. The method of claim 1 , wherein the patch comprises chitosan, extracellular matrix, or a combination thereof.
3. The method of claim 1 , wherein the cap has a frustoconical shape and a ridge on an outer surface of the cap.
4. The method of claim 1 , wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.
5. The method of claim 1 , wherein the cap is fixedly coupled to the distal end of the endoscope.
6. The method of claim 1 , wherein releasing the patch from the cap includes applying pressure to the patch with the endoscope.
7. A method of delivering a patch to a target site of a patient, the method comprising:
introducing a system comprising an endoscope into a gastrointestinal tract of a patient, wherein the system includes a patch comprising a biocompatible material and
a cap fixedly coupled to a distal end of the endoscope, wherein the patch is secured to an outer surface of the cap with a flexible band, covers a distal opening of the cap, and is releasable from the cap;
positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from cap;
wherein releasing the patch from the cap includes actuating a wire to release the flexible band.
8. The method of claim 7 , wherein applying the patch includes blowing air or spraying water from a channel of the endoscope onto the patch.
9. The method of claim 7 , wherein releasing the patch from the cap includes actuating the wire to cut the flexible band, and a portion of the flexible band remains tethered to the cap after the flexible band is cut.
10. A medical system comprising:
an endoscope defining at least one working channel;
a patch comprising a biocompatible material; and
a cap coupled to a distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band;
wherein a wire extending through the at least one working channel is coupled to the flexible band;
wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.