Sesquiterpenoid analogs
The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.
1. A method of inhibiting; Src homology domain containing phosphatase 2 (SHP2) in a patient with cancer, which method comprises administering to the patient a compound of:
or any stereoisomer of the foregoing or a combination thereof,
whereupon SHP2 in the patient with cancer is inhibited.
2. The method of claim 1 , wherein the compound is Formula III or any stereoisomer thereof.
3. The method of claim 1 , wherein the patient is being treated with a DNA damaging drug.
4. The method of claim 3 , wherein the DNA damaging drug is ectoposide.
5. The method of claim 2 , wherein the patient is being treated with a DNA damaging drug.
6. The method of claim 5 , wherein the DNA damaging drug is ectoposide.