TREPROSTINIL ADMINISTRATION BY INHALATION
Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.
1 . A method of treating pulmonary hypertension comprising administering by inhalation to a human suffering from pulmonary hypertension a therapeutically effective single event dose of a formulation comprising treprostinil or a pharmaceutically acceptable salt thereof with an inhalation device, wherein the therapeutically effective single event dose comprises from 15 micrograms to 90 micrograms of treprostinil or a pharmaceutically acceptable salt thereof delivered in 1 to 3 breaths.
2 . The method of claim 1 , wherein the inhalation device is a soft mist inhaler.
3 . The method of claim 1 , wherein the inhalation device is a pulsed ultrasonic nebulizer.
4 . The method of claim 1 , wherein the inhalation device is a dry powder inhaler.
5 . The method of claim 1 , wherein the inhalation device is a pressurized metered dose inhaler.
6 . An inhalation device for treating pulmonary hypertension in a human suffering from pulmonary hypertension comprising an inhalation device configured to administer a therapeutically effective single event dose of a formulation comprising treprostinil or a pharmaceutically acceptable salt thereof, wherein the therapeutically effective single event dose comprises from 15 micrograms to 90 micrograms of treprostinil or a pharmaceutically acceptable salt thereof delivered in 1 to 3 breaths.
7 . The inhalation device of claim 6 , wherein the inhalation device is a soft mist inhaler.
8 . The inhalation device of claim 6 , wherein the inhalation device is a pulsed ultrasonic nebulizer.
9 . The inhalation device of claim 6 , wherein the inhalation device is a dry powder inhaler.
10 . The inhalation device of claim 6 , wherein the inhalation device is a pressurized metered dose inhaler.