ACECLIDINE ISOMERS AND SCALEMIC MIXTURES THEREOF FOR THE TREATMENT OF PRESBYOPIA
The invention provides compositions containing aceclidine isomers and scalemic mixtures thereof for the treatment of presbyopia. The compositions optionally contain an alpha-adrenergic agonist, a cycloplegic agent, a cryoprotectant, a non-ionic surfactant and/or a viscosity enhancer.
1 . A composition for the treatment of presbyopia comprising aceclidine wherein the S-enantiomer of aceclidine is greater than 50% by weight of the aceclidine.
2 . The composition of claim 1 , wherein the S-enantiomer is at least 60% by weight of the mixture.
3 . The composition of claim 1 , wherein the S-enantiomer is at least 70% by weight of the aceclidine.
4 . The composition of claim 1 , wherein the S-enantiomer is at least 80% by weight of the aceclidine.
5 . The composition of claim 1 , wherein the S-enantiomer is at least 90% by weight of the aceclidine.
6 . The composition of claim 1 , wherein the S-enantiomer is at least 99% by weight of the aceclidine.
7 . The composition of claim 1 , wherein the S-enantiomer is 100% by weight of the aceclidine.
8 . The composition of claim 1 , further comprising one or more agents selected from the group consisting of an alpha-adrenergic agonist, a cycloplegic agent, a cryoprotectant, a non-ionic surfactant and a viscosity agent.
9 . The composition of claim 1 , further comprising one or more preservatives.
10 . A method of treating presbyopia comprising administering the composition of claim 1 to a subject in need thereof.
11 . A composition for the treatment of presbyopia comprising aceclidine wherein the R-enantiomer of aceclidine is greater than 50% by weight of the aceclidine.
12 . The composition of claim 10 , wherein the R-enantiomer is at least 60% by weight of the mixture.
13 . The composition of claim 1 , wherein the R-enantiomer is at least 70% by weight of the aceclidine.
14 . The composition of claim 10 , wherein the R-enantiomer is at least 80% by weight of the aceclidine.
15 . The composition of claim 10 , wherein the R-enantiomer is at least 90% by weight of the aceclidine.
16 . The composition of claim 10 , wherein the R-enantiomer is at least 99% by weight of the aceclidine.
17 . The composition of claim 10 , wherein the R-enantiomer is 100% by weight of the aceclidine.
18 . The composition of claim 10 , further comprising one or more agents selected from the group consisting of an alpha-adrenergic agonist, a cycloplegic agent, a cryoprotectant, a non-ionic surfactant and a viscosity agent.
19 . The composition of claim 10 , further comprising one or more preservatives.
20 . A method of treating presbyopia comprising administering the composition of claim 10 to a subject in need thereof.