PH indicator swabs for biomonitoring and diagnostics
Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.
1. A medical swab comprising:
a swab surface;
a crosslinked absorbent hydrogel matrix comprising a biocompatible polymer at the swab surface;
a photoinitiator; and
a pH indicator retained within the crosslinked absorbent hydrogel matrix, the pH indicator exhibiting a detectable color change in the visible spectrum that is indicative of the pH of a fluid in contact with the pH indicator.
2. The medical swab of claim 1 , the crosslinked absorbent hydrogel matrix comprising a plasticizer.
3. The medical swab of claim 2 , the plasticizer comprising dioctylphthalate, castor oil, diacetylated monoglycerides, diethyl phthalate, glycerin, mono- and di-acetylated monoglycerides, polyethylene glycol, propylene glycol, triacetin, triethyl citrate, bis-(2-butoxyethyl) adipate, and bis-(2-ethylhexyl) sebacate polyvinyl alcohol, polyvinyl alcohol, glycerol, or polyethylene glycol.
4. The medical swab of claim 1 , the biocompatible polymer comprising an alginate, a collagen, a gelatin, a cellulose, a poly(lactic-co-glycolic acid), a polycaprolactone, or derivatives or combinations thereof.
5. The medical swab of claim 1 , the pH indicator comprising litmus, anthocyanin, nitrazine yellow, brilliant yellow, cresol red, bromcresol purple, chlorophenol red, bromothymol blue, thymol blue, bromoxylenol blue, neutral red, phenol red, xylenol blue, m-cresol purple, orcein, erythrolitmin (or erythrolein), azolitmin, spaniolitmin, leucoorcein, leucazolitmin, or any combination thereof.
6. The medical swab of claim 1 , the medical swab further comprising a support substrate, wherein the crosslinked absorbent hydrogel matrix is coated on the support substrate.
7. The medical swab of claim 6 , the support substrate comprising an absorptive substrate.
8. The medical swab of claim 7 , the absorptive substrate comprising fibers, a foam, or a sponge.
9. The medical swab of claim 6 , the support substrate comprising polyurethane, polyester, or cotton.
10. The medical swab of claim 6 , the support substrate comprising a hollow or solid structure of molded plastic, paper or wood.
11. The medical swab of claim 1 , wherein the photoinitiator comprises a benzoyl radical.