Granted Patent
B2
US 12,611,107 · App. 16/549,814 · Granted Apr 28, 2026
Lumen morphology and vascular resistance measurements data collection systems, apparatus and methods
Inventors:
Joseph M. Schmitt (Andover, MA); Joel M. Friedman (Andover, MA); Christopher Petroff (Groton, MA); Amr Elbasiony (Chelmsford, MA)
Assignee:
LightLab Imaging, Inc.
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Abstract
A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.
Claims (41)
1 . An automated computer-based method of evaluating an artery,
the method comprising:
collecting a set of image data relative to a segment of an artery of length L;
detecting a lumen boundary of the segment of the artery using the set of image data;
generating a two-dimensional representation of the segment of the artery; and
displaying the two-dimensional representation of the artery using a software-based user interface of an imaging system,
the two-dimensional representation of the artery comprising a profile based on the detected lumen boundary, wherein the profile represents cross-sectional area or mean cross-sectional diameter values of the vessel that are arranged to be cylindrically symmetric relative to a longitudinal axis of the representation, and wherein the two-dimensional representation includes one or more vessel branch indicators positioned along the longitudinal axis of the representation based on positions of side branches within the artery.
2 . The method of claim 1 , wherein the two-dimensional representation of the artery further comprises a proximal reference frame and a distal reference frame.
3 . The method of claim 1 further comprising automatically tracing contours of wall of lumen, using image data, and displaying the traced contours.
4 . The method of claim 1 further comprising determining a minimum lumen area (MLA) of the segment; and identifying a frame corresponding to the MLA in the two-dimensional representation.
5 . The method of claim 1 , wherein the software-based user interface displays a minimum lumen area value.
6 . The method of claim 1 , wherein the two-dimensional representation of the artery further comprises one or more percent stenosis values.
7 . The method of claim 1 , wherein the two-dimensional representation of the artery further comprises a vertical axis corresponding to diameter values.
8 . The method of claim 5 , wherein the two-dimensional representation of the artery further comprises a horizontal axis along the segment of the artery.
9 . The method of claim 1 further comprising detecting one or more side branches in the set of image data and displaying a representation of the one or more side branches.
10 . The method of claim 1 further comprising detecting a stent in the segment and displaying a stent representation.
11 . The method of claim 10 further comprising displaying one or more indications of stent malapposition relative to the stent representation.
12 . The method of claim 1 further comprising simulating placement of a stent, in response to one or more user commands, relative to one or more images of the segment of the artery.
13 . An automated computer-based method of evaluating an artery, the method comprising:
collecting a set of image data relative to a segment of an artery of length L;
determining diameter values along length L;
generating a two-dimensional representation of the segment of the artery using the diameter values; and
displaying the two-dimensional representation of the artery using a software-based user interface of an imaging system,
the two-dimensional representation of the artery comprising a profile of a lumen region that is based on a boundary region, the profile having a first axis corresponding to cross-sectional area or mean cross-sectional diameter values, and a second axis along the length L, wherein the arrangement of cross-sectional area or mean cross-sectional diameter values is cylindrically symmetric about the second axis, and wherein the two-dimensional representation includes one or more vessel branch indicators positioned along the longitudinal axis of the representation based on positions of side branches within the artery.
14 . The method of claim 13 , wherein the two-dimensional representation of the artery is symmetric about an axis.
15 . The method of claim 13 , wherein one or more of lumen region and boundary region are different colors.
16 . The method of claim 13 , wherein the software-based user interface displays a minimum lumen area value.
17 . The method of claim 13 , wherein software-based user interface display one or more percent stenosis values.
18 . The method of claim 13 further comprising detecting one or more side branches in the set of image data and displaying a representation of the one or more side branches using a software-based user interface.
19 . The method of claim 13 further comprising detecting a stent in the segment and displaying a stent representation.
20 . The method of claim 19 further comprising displaying one or more indications of stent malapposition relative to the stent representation.
21 . The method of claim 13 , wherein the image data comprises a plurality of scan lines or frames.
22 . An automated computer-based method of evaluating an artery, the method comprising:
collecting a set of image data relative to a segment of an artery of length L;
determining cross-sectional area values along length L;
generating a two-dimensional representation of the segment of the artery using the area values; and
displaying the two-dimensional representation of the artery using a software-based user interface of an imaging system,
the two-dimensional representation of the artery comprising a profile of a lumen region that is based on a boundary region, the profile having a first axis corresponding to cross-sectional area or mean cross-sectional diameter values, and a second axis along the representation of the artery, wherein the two-dimensional representation of the artery is cylindrically symmetric about the second axis, and wherein the two-dimensional representation includes one or more vessel branch indicators positioned along the longitudinal axis of the representation based on positions of side branches within the artery.
23 . The method of claim 22 , wherein one or more of the lumen region and the boundary region are different colors.
24 . The method of claim 22 , wherein the software-based user interface displays a minimum lumen area value.
25 . The method of claim 22 , wherein software-based user interface display one or more percent stenosis values.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 29, 2020
From: SCHMITT, JOSEPH M.; FRIEDMAN, JOEL M.; PETROFF, CHRISTOPHER; ELBASIONY, AMR
To: LIGHTLAB IMAGING, INC.
Reel/Frame 054209/0880 →
Continuity (5)
Provisional Application
61334834
· May 14, 2010
Provisional Application
61244992
· Sep 23, 2009
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