Modulation of complement activity
The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
1. A compound comprising the structure of
2. The compound of claim 1 , wherein the compound is conjugated to the side chain amine group of lysine to yield
3. The compound of claim 2 , wherein the lysine residue is part of a polypeptide.
4. The compound of claim 3 , wherein the lysine residue is the C-terminal residue of the polypeptide.
5. A method of modifying a polypeptide, the method comprising conjugating the polypeptide with a compound comprising the structure of
6. The method of claim 5 , wherein the compound is conjugated to the side chain amine group of lysine.
7. A method of synthesizing a polypeptide, the method comprising incorporating a modified lysine residue into the polypeptide, wherein the modified lysine residue comprises the structure of