Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
1. A compound selected from:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
8. The pharmaceutical composition of claim 7 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
9. The pharmaceutical composition of claim 7 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
10. The pharmaceutical composition of claim 7 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
11. The pharmaceutical composition of claim 7 , wherein the compound is
or a pharmaceutically acceptable salt thereof.