Hydropneumatic artificial intervertebral disc
An artificial intervertebral disc (IVD) is provided for replacement of a degenerated intervertebral disc. The artificial IVD includes two endplates having oppositely-facing outward surfaces configured to engage respective intervertebral surfaces of the spinal column, and a chamber, which is disposed between oppositely-facing inner surfaces of the two endplates, and which includes a lateral wall including an electroosmotic membrane. A plurality of exposed electrode surface includes (i) one or more intra-chamber exposed electrode surfaces, which are located within the chamber; and (ii) one or more extra-chamber exposed electrode surfaces, which are located outside the chamber, in a vicinity of the chamber. Control circuitry is configured to drive at least one of the one or more intra-chamber exposed electrode surfaces and at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive liquid from outside the chamber to inside the chamber. Other embodiments are also described.
1. Apparatus comprising:
(a) an artificial intervertebral disc (IVD) for replacement of a degenerated intervertebral disc in a spinal column of a subject, the artificial IVD comprising:
two endplates having oppositely-facing outward surfaces configured to engage respective intervertebral surfaces of the spinal column;
a chamber, which is disposed between oppositely-facing inner surfaces of the two endplates, and which comprises a lateral wall comprising an electroosmotic membrane; and
a plurality of exposed electrode surfaces, including (i) one or more intra-chamber exposed electrode surfaces, which are located within the chamber; and (ii) one or more extra-chamber exposed electrode surfaces, which are located outside the chamber, in a vicinity of the chamber; and
(b) control circuitry, which is configured to:
drive at least one of the one or more intra-chamber exposed electrode surfaces and at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive liquid from outside the chamber to inside the chamber, and
drive at least two of the exposed electrode surfaces to increase a pressure in the chamber by generating a gas in the chamber by electrolysis of water of the liquid in the chamber.
2. The apparatus according to claim 1 , wherein the control circuitry is configured to drive the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive the liquid from outside the chamber to inside the chamber by configuring the at least one of the intra-chamber exposed electrode surfaces to be a cathode, and the at least one of the extra-chamber exposed electrode surfaces to be an anode.
3. The apparatus according to claim 1 , wherein the artificial IVD further comprises a wire coil, which is configured to receive electromagnetically transmitted energy for electroosmotically driving the liquid from outside the chamber to inside the chamber.
4. The apparatus according to claim 1 ,
wherein the artificial IVD further comprises a pressure sensor, which is arranged to sense a pressure within the chamber, and
wherein the control circuitry is configured to drive the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive the liquid at least in part based on the sensed pressure.
5. The apparatus according to claim 1 , wherein the control circuitry is configured to drive the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive the liquid by applying a voltage of no more than 1.2 V between the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces.
6. The apparatus according to claim 1 ,
wherein the artificial IVD comprises a plurality of the intra-chamber exposed electrode surfaces, and
wherein the control circuitry is configured to drive at least two of the intra-chamber exposed electrode surfaces to generate the gas in the chamber by electrolysis of water of the liquid in the chamber.
7. The apparatus according to claim 1 , wherein the control circuitry is configured to drive at least one of the one or more intra-chamber exposed electrode surfaces and at least one of the one or more extra-chamber exposed electrode surfaces to generate the gas in the chamber by electrolysis of water of the liquid in the chamber.
8. The apparatus according to claim 7 , wherein the control circuitry is configured to drive the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces to generate the gas in the chamber by configuring the at least one of the intra-chamber exposed electrode surfaces to be an anode, and the at least one of the extra-chamber exposed electrode surfaces to be a cathode.
9. The apparatus according to claim 1 , wherein the control circuitry is configured to:
ascertain a level of motion of the artificial IVD, and
drive the at least two of the exposed electrode surfaces to generate the gas at least in part based on the ascertained level of motion.
10. The apparatus according to claim 9 ,
wherein the artificial IVD further comprises a motion sensor, which is arranged to sense the level of motion of the artificial IVD, and
wherein the control circuitry is configured to ascertain the level of motion based on the level of motion sensed by the motion sensor.
11. The apparatus according to claim 9 ,
wherein the artificial IVD further comprises a pressure sensor, which is arranged to sense a pressure within the chamber, and
wherein the control circuitry is configured to ascertain the level of motion based on a rate of change of the sensed pressure within the chamber.
12. The apparatus according to claim 1 ,
wherein the artificial IVD further comprises a pressure sensor, which is arranged to sense a pressure within the chamber, and
wherein the control circuitry is configured to drive, at least in part based on the sensed pressure, the at least two of the exposed electrode surfaces to generate the gas.
13. The apparatus according to claim 1 , wherein the artificial IVD further comprises a flexible support, which is disposed between the two endplates and regulates relative movement of the two endplates.
14. The apparatus according to claim 13 , wherein the chamber is annular and surrounds the flexible support.
15. The apparatus according to claim 14 , wherein the flexible support is shaped so as to define a compartment.
16. The apparatus according to claim 15 , wherein the artificial IVD further comprises a wire coil, which is located within the compartment of the flexible support, and is configured to receive electromagnetically transmitted energy for electroosmotically driving the liquid from outside the chamber to inside the chamber.
17. The apparatus according to claim 15 , wherein the artificial IVD further comprises a motion sensor, which is located within the compartment of the flexible support.
18. The apparatus according to claim 1 , wherein the control circuitry is configured to:
ascertain a level of motion of the artificial IVD, and
drive the at least one of the one or more intra-chamber exposed electrode surfaces and the at least one of the one or more extra-chamber exposed electrode surfaces to electroosmotically drive the liquid at least in part based on the ascertained level of motion.
19. The apparatus according to claim 18 ,
wherein the artificial IVD further comprises a pressure sensor, which is arranged to sense a pressure within the chamber, and
wherein the control circuitry is configured to ascertain the level of motion based on a rate of change of the sensed pressure within the chamber.
20. The apparatus according to claim 1 , wherein the artificial IVD further comprises a band, which is disposed outside and surrounding the lateral wall of the chamber, and which is configured to constrain lateral expansion of the chamber.
21. The apparatus according to claim 20 , wherein the band comprises a metal, and serves as the one or more extra-chamber exposed electrode surfaces.
22. A system comprising the apparatus according to claim 1 , wherein the system further comprises a delivery shaft in which the artificial IVD is removably disposed in a collapsed configuration.
23. The system according to claim 22 , wherein when the artificial IVD is in the collapsed configuration, the outward surface of one of the two endplates is concave when viewed from outside the artificial IVD and the outward surface of the other of the two endplates is convex when viewed from outside the artificial IVD.
24. A method of treating a spinal column of a subject, the method comprising:
removing a degenerated intervertebral disc from between intervertebral surfaces of the spinal column;
implanting an artificial intervertebral disc (IVD), which includes a plurality of exposed electrode surfaces, including one or more intra-chamber exposed electrode surfaces and one or more extra-chamber exposed electrode surfaces, such that (a) oppositely-facing outward surfaces of two endplates of the artificial IVD engage the intervertebral surfaces of the spinal column, respectively, and (b) the one or more extra-chamber exposed electrode surfaces of the artificial IVD are located outside a chamber of the artificial IVD, in a vicinity of the chamber, wherein the chamber is disposed between oppositely-facing inner surfaces of the two endplates, and includes a lateral wall including an electroosmotic membrane, and wherein the one or more intra-chamber exposed electrode surfaces are located within the chamber; and
activating control circuitry to (i) drive at least one of the intra-chamber exposed electrode surfaces and at least one of the extra-chamber exposed electrode surfaces to electroosmotically drive liquid from outside the chamber to inside the chamber, and (ii) drive at least two of the exposed electrode surfaces to increase a pressure in the chamber by generating a gas in the chamber by electrolysis of water of the liquid in the chamber.
25. The method according to claim 24 , wherein implanting the artificial IVD comprises implanting the artificial IVD while the chamber is deflated.
26. The method according to claim 25 , wherein implanting the artificial IVD while the chamber is deflated comprises implanting the artificial IVD while the outward surface of one of the two endplates is concave when viewed from outside the artificial IVD and the outward surface of the other of the two endplates is convex when viewed from outside the artificial IVD.
27. The method according to claim 25 , wherein implanting the artificial IVD while the chamber is deflated comprises implanting the artificial IVD while the artificial IVD is in a collapsed configuration removably disposed in a delivery shaft.
28. The method according to claim 24 , wherein the artificial IVD further includes a flexible support, which is disposed between the two endplates and regulates relative movement of the two endplates.