Iloperidone for the treatment of schizophrenia
Aspects of the invention relate generally to the treatment of schizophrenia in an individual and, more specifically, to the treatment of an individual with iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt thereof. In one embodiment, the invention provides a method of preventing schizophrenic relapse in an individual diagnosed with schizophrenia, the method comprising: administering to the individual iloperidone, an iloperidone metabolite, or a pharmaceutically-acceptable salt thereof at a daily dose between about 12 mg and about 16 mg following a period in which the individual's schizophrenia was stabilized.
1. In a method consisting essentially of treating a schizophrenia patient by administering therapeutic amounts of a compound that is iloperidone or P88 or a pharmaceutically-acceptable salt of iloperidone or P88 daily, the improvement comprising:
after completion of an acute treatment phase in which the schizophrenia patient is administered the compound at a first dose of 12-24 mg/day, reducing the amount of the compound administered daily to a second dose that is both smaller than the first dose and in a range of 8-16 mg/day.
2. The improvement of claim 1 , wherein the first dose is 16-24 mg/day, and the second dose is 12-16 mg/day.
3. The improvement of claim 2 , wherein the first dose of 16-24 mg/day is orally administered as 8-12 mg twice daily, and the second dose of 12-16 mg/day is orally administered as 6-8 mg twice daily.
4. The improvement of claim 1 , wherein the second dose is about 75% of the first dose.
5. The improvement of claim 2 , wherein the first dose is about 16 mg/day and the second dose is about 12 mg/day.
6. The improvement of claim 1 , wherein the first dose is about 12 mg/day and the second dose is about 8 mg/day.
7. The improvement of claim 1 , wherein the second dose is about 50% of the first dose.
8. The improvement of claim 7 , wherein the first dose is about 24 mg/day and the second dose is about 12 mg/day.
9. The improvement of claim 7 , wherein the first dose is about 16 mg/day and the second dose is about 8 mg/day.
10. The improvement of claim 1 , wherein the second dose is between about 12 mg/day and about 16 mg/day.
11. The improvement of claim 10 , wherein the second dose is between about 12 mg/day and about 14 mg/day.
12. The improvement of claim 1 , wherein the compound is iloperidone or a pharmaceutically acceptable salt thereof.
13. The improvement of claim 1 , wherein the compound is P88 or a pharmaceutically acceptable salt thereof.