Analgesic compositions
The present invention provides compositions useful in reducing or preventing pain in a subject in need thereof. In one embodiment, the compositions comprise a halogenated volatile compound. The present invention further includes a method of reducing or preventing pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a composition of the invention. Dosing regimens contemplated within the invention include one-time administration, continuous administration or periodic administration.
1. An uniform composition comprising a halogenated volatile compound and a poloxamer,
wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof, and
wherein the composition is uniform.
2. The composition of claim 1 , further comprising at least one component selected from the group consisting of
an alcohol;
2-(2-ethoxyethoxy)-ethanol;
a polyol;
an organic solvent;
an organic carbonate;
hydroxypropyl cellulose (HPC);
a fatty acid or a salt thereof;
a polyethylene glycol (PEG);
a polyethyne glycol (PPG);
a monoester of a (methyl vinyl ether-maleic acid) co-polymer;
a copolymer of 2-(2-hydroxypropoxy)propan-1-ol (PPG-12) and 1-methylene bis-4-isocyanatocyclohexane (SMDI);
saccharine; and any combinations thereof;
wherein the organic solvent is selected from the group consisting of dimethylsulfoxide (DMSO), dimethylisosorbide, and any mixtures thereof; and
wherein the organic carbonate is selected from the group consisting of propylene carbonate, ethylene carbonate, and any mixtures thereof.
3. The composition of claim 1 , comprising from about 5% to about 95% w/w halogenated volatile compound.
4. The composition of claim 3 , comprising from about 50% to about 90% w/w halogenated volatile compound.
5. The composition of claim 2 , wherein the alcohol is selected from the group consisting of methanol, ethanol, n-propanol, isopropanol, n-butanol, sec-butanol, isobutanol, t-butanol, and any mixtures thereof.
6. The composition of claim 2 , comprising from about 2% to about 20% w/w alcohol.
7. The composition of claim 6 , wherein the alcohol is ethanol and the composition comprises about 8.25% w/w ethanol.
8. The composition of claim 2 , comprising from about 5% to about 10% w/w 2-(2-ethoxyethoxy)-ethanol.
9. The composition of claim 2 , comprising from about 5% to about 20.25% w/w polyol.
10. The composition of claim 9 , comprising about 5% w/w polyol.
11. The composition of claim 2 , comprising from about 5% to about 50% w/w organic solvent.
12. The composition of claim 11 , comprising from about 10% to about 50% w/w organic solvent.
13. The composition of claim 2 , comprising about 2.5% w/w organic carbonate.
14. The composition of claim 2 , comprising from about 1% to about 5% w/w HPC.
15. The composition of claim 14 , comprising about 1.75% w/w HPC.
16. The composition of claim 2 , wherein the fatty acid or salt thereof is selected from the group consisting of myristoleic acid, palmitoleic acid, sapienic acid, oleic acid, elaidic acid, vaccenic acid, linoleic acid, linoelaidic acid, α-linolenic acid, arachidonic acid, eicosapentaenoic acid, erucic acid, docosahexaenoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, and any combinations thereof.
17. The composition of claim 2 , comprising from about 1% to about 5% w/w fatty acid or a salt thereof.
18. The composition of claim 17 , comprising about 3% w/w fatty acid or a salt thereof.
19. The composition of claim 2 , wherein the PEG is selected from the group consisting of PEG-200, PEG-300, PEG-400, PEG-600, PEG-[950-1,050], PEG-1,000, PEG-[1,300-1,600], PEG-[1,305-1,595], PEG-1,450, PEG-1,500, PEG-2,000, PEG-2,050, PEG-3,000, PEG-[3,000-3,700], PEG-3,350, PEG-4,000, PEG-4,600, PEG-6,000, PEG-8,000, PEG-10,000, PEG-12,000, PEG-20,000, PEG-35,000, and any mixtures thereof.
20. The composition of claim 2 , comprising from about 6% to about 78% w/w PEG.
21. The composition of claim 20 , comprising about 6% w/w PEG.
22. The composition of claim 2 , wherein the monoester of a (methyl vinyl ether-maleic acid) co-polymer is n-butyl, isopropyl, ethyl, or any mixtures thereof.
23. The composition of claim 2 , comprising from about 15% to about 20% w/w monoester of a (methyl vinyl ether-maleic acid) co-polymer.
24. The composition of claim 23 , comprising about 20% w/w monoester of a (methyl vinyl ether-maleic acid) co-polymer.
25. The composition of claim 2 , comprising from about 5% to about 15% w/w copolymer of PPG-12 and SMDI.
26. The composition of claim 25 , comprising about 10% w/w copolymer of PPG-12 and SMDI.
27. The composition of claim 2 , comprising about 2% w/w saccharine.
28. The composition of claim 2 , comprising from about 15% to about 20% w/w PPG.
29. The composition of claim 1 , comprising from about 1% to about 5% w/w poloxamer.
30. The composition of claim 29 , wherein the poloxamer comprises poloxamer 188, poloxamer 407, and any mixtures thereof.
31. The composition of claim 1 , wherein the composition comprises about 3% w/w oleic acid, about 15% w/w propylene glycol, about 14.25% w/w ethanol, about 1.75% w/w HPC, about 1% w/w poloxamer 407, about 5% w/w poloxamer 188, and about 60% w/w isoflurane.
32. The composition of claim 1 , wherein the composition is incorporated in a medical patch.
33. A method of reducing or ameliorating pain in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an uniform composition comprising a halogenated volatile compound and a poloxamer, wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof, and wherein the composition is uniform, whereby pain in the subject is reduced or ameliorated.
34. The method of claim 33 , wherein the composition is administered locally or regionally.
35. The method of claim 33 , wherein the composition is administered by at least one route from the group selected from intrathecally, epidurally, transdermally, topically, mucosally, buccally, rectally, vaginally, intramuscularly, subcutaneously, by local skin infiltration, and in a nerve block procedure.
36. The method of claim 33 , wherein the pain comprises chronic pain or acute pain.
37. The method of claim 33 , wherein the administration of the composition is continuous, periodic, or a one-time event.
38. The method of claim 33 , wherein the administration of the composition is both periodically administered and continuously administered to the subject on separate occasions.
39. The method of claim 33 , wherein the continuous delivery is achieved by a transdermal route or an infusion pump.
40. The method of claim 33 , wherein the pain reduction or prevention is achieved with little or no inhibition of motor function of the subject.
41. The method of claim 33 , wherein the composition comprises about 3% w/w oleic acid, about 15% w/w propylene glycol, about 14.25% w/w ethanol, about 1.75% w/w HPC, about 1% w/w poloxamer 407, about 5% w/w poloxamer 188, and about 60% w/w isoflurane.
42. The method of claim 33 , wherein the subject is a mammal.
43. The method of claim 42 , wherein the subject is human, mouse or rat.
44. A method of dressing a wound in a subject in need thereof, the method comprising applying to the wound a therapeutically effective amount of an uniform composition comprising a halogenated volatile compound and a poloxamer, wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof, and wherein the composition is uniform.
45. The method of claim 44 , wherein the wound is in the skin of the subject.
46. The method of claim 44 , wherein the composition is incorporated in a medical patch.
47. The method of claim 44 , wherein the subject is a mammal.
48. The method of claim 47 , wherein the subject is human, mouse or rat.
49. The composition of claim 6 , wherein the alcohol is ethanol and the composition comprises about 10% w/w ethanol.
50. The composition of claim 6 , wherein the alcohol is ethanol and the composition comprises about 12.5% w/w ethanol.
51. The composition of claim 9 , comprising about 15.25% w/w polyol.
52. The composition of claim 14 , comprising about 2% w/w HPC.
53. The composition of claim 14 , comprising about 2.25% w/w HPC.
54. The composition of claim 14 , comprising about 5% w/w HPC.
55. The composition of claim 20 , comprising about 20% w/w PEG.
56. The composition of claim 20 , comprising about 20.5% w/w PEG.