Solution target for cyclotron production of radiometals
Methods of producing and isolating 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99m Tc, 45 Ti, 13 N, 52 Mn, or 44 Sc and solution targets for use in the methods are disclosed. The methods of producing 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99m Tc, 45 Ti, 13 N, 52 Mn, or 44 Sc include irradiating a closed target system with a proton beam. The system can include a solution target. The methods of producing isolated 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99m Tc, 45 Ti, 52 Mn, or 44 Sc further include isolating 68 Ga, 89 Zr, 64 Cu, 63 Zn, 86 Y, 61 Cu, 99m Tc, 45 Ti, 52 Mn, or 44 Sc by ion exchange chromatography. An example target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
1. A method for synthesizing a functionalized resin for trapping an analyte, the method comprising:
(a) providing a cationic exchange resin having carboxylate groups;
(b) activating carboxylate groups of the cationic exchange resin with an activating agent; and
(c) reacting activated carboxylate groups of the cationic exchange resin with a hydroxylamine salt in the presence of a base to produce the functionalized resin,
wherein the activating agent comprises an alkyl ester of chloroformic acid.
2. The method of claim 1 wherein:
the activating agent comprises methyl chloroformate.
3. The method of claim 1 wherein:
the base comprises an amine.
4. The method of claim 3 wherein:
the base is a tertiary amine.
5. The method of claim 3 wherein:
the base is triethylamine.
6. The method of claim 1 wherein:
the hydroxylamine salt s hydroxylamine hydrochloride.
7. The method of claim 1 wherein:
step (b) is undertaken in the presence of a solvent for the activating agent.
8. The method of claim 7 wherein:
the solvent comprises a halogenated alkane.
9. The method of claim 7 wherein:
the solvent is dichloromethane.
10. The method of claim 7 further comprising:
removing the solvent under vacuum.
11. The method of claim 1 wherein:
the analyte is a radionuclide.
12. The method of claim 11 wherein:
the radionuclide is 89 Zr.
13. The method of claim 1 further comprising:
(d) packing the functionalized resin into a cartridge.
14. The method of claim 1 wherein:
the functionalized resin has a 89 Zr elution efficiency of 40%-95% when eluting 89 Zr from the functionalized resin with a phosphate eluent.
15. The method of claim 1 wherein:
the functionalized resin has a 89 Zr elution efficiency of 90%-95% when eluting 89 Zr from the functionalized resin with a phosphate eluent.
16. The method of claim 1 wherein:
the functionalized resin has a 89 Zr trapping efficiency of 93%-97%.
17. The method of claim 1 wherein:
the method is a one-pot synthesis method.
18. The method of claim 1 wherein:
the functionalized resin is a hydroxamate functionalized resin.
19. A method for synthesizing a hydroxamate functionalized resin for trapping an analyte, the method comprising:
(a) providing a cationic exchange resin having carboxylate groups;
(b) activating carboxylate groups of the cationic exchange resin with an alkyl ester of a haloformic acid; and
(c) reacting activated carboxylate groups of the cationic exchange resin with hydroxylamine hydrochloride in the presence of a tertiary amine to produce the hydroxamate functionalized resin.
20. A method for synthesizing a functionalized resin for trapping an analyte, the method comprising:
(a) providing a cationic exchange resin having carboxylate groups;
(b) activating carboxylate groups of the cationic exchange resin with an activating agent; and
(c) reacting activated carboxylate groups of the cationic exchange resin with a hydroxylamine salt in the presence of a base to produce the functionalized resin,
wherein the base comprises an amine.
21. The method of dam 20 wherein:
the base is a tertiary amine.
22. The method of claim 20 wherein:
the base is triethylamine.