THERAPEUTIC AGENT FOR ANXIETY DISORDERS
Provided are an agent for the treatment and/or prophylaxis of an anxiety disorder comprising, as an active ingredient, a thiazole derivative represented by the formula (I) wherein R 1 represents aryl or the like, and R 2 represents pyridyl or the like, or a pharmaceutically acceptable salt thereof, and the like.
1 . An agent for the treatment and/or prophylaxis of an anxiety disorder, comprising a thiazole derivative represented by the formula (I)
wherein R 1 represents aryl, aralkyl, an aromatic heterocyclic group, aromatic heterocyclyl-alkyl, aliphatic heterocyclyl-alkyl or tetrahydropyranyloxy, each of which is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen; lower alkyl optionally substituted by lower alkoxy or morpholino; lower alkoxy; lower alkanoyl; and vinyl, and R 2 represents pyridyl or tetrahydropyranyl,
or a pharmaceutically acceptable salt thereof as an active ingredient.
2 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 1 , wherein R 1 1841 is phenyl, pyridyl, pyrimidinyl, 5,6-dihydro-2H-pyridylmethyl or tetrahydropyranyloxy, each of which is optionally substituted by 1 to 3 substituents selected from a fluorine atom, a chlorine atom, a bromine atom, methyl, ethyl, methoxy and ethoxy, and R 2 is pyridyl or tetrahydropyranyl.
3 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 1 , wherein R 1 is pyridyl or pyrimidinyl, each of which is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen; lower alkyl optionally substituted by lower alkoxy or morpholino; lower alkoxy; lower alkanoyl; and vinyl.
4 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 3 , wherein R 2 is pyridyl.
5 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 3 , wherein R 2 is tetrahydropyranyl.
6 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 1 , wherein the thiazole derivative represented by the formula (I) is a compound represented by any one of the following formulas (IA)-(IAA).
7 . The agent for the treatment and/or prophylaxis of an anxiety disorder, comprising the thiazole derivative or the pharmaceutically acceptable salt thereof according to claim 1 , wherein the thiazole derivative represented by the formula (I) is a compound represented by any one of the following formulas (IA)-(ID).
8 . The agent according to any one of claim 6 , wherein the anxiety disorder is panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, posttraumatic stress disorder, particular phobia or generalized anxiety disorder.
9 . A method of treating and/or preventing an anxiety disorder, comprising administering an effective amount of the thiazole derivative according to claim 6 , or the pharmaceutically acceptable salt thereof.
10 . The method according to claim 9 , wherein the anxiety disorder is panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, posttraumatic stress disorder, particular phobia or generalized anxiety disorder.
11 . The thiazole derivative according to claim 6 , or the pharmaceutically acceptable salt thereof, for use in the treatment and/or prophylaxis of an anxiety disorder.
12 . The thiazole derivative according to claim 11 or the pharmaceutically acceptable salt thereof, wherein the anxiety disorder is panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, posttraumatic stress disorder, particular phobia or generalized anxiety disorder.
13 . Use of the thiazole derivative according to claim 6 , or the pharmaceutically acceptable salt thereof, for the production of an agent for the treatment and/or prophylaxis of an anxiety disorder.
14 . The use according to claim 13 , wherein the anxiety disorder is panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, posttraumatic stress disorder, particular phobia or generalized anxiety disorder.