Methods for treating relaxed hair
Methods and kits for treating hair or preventing damage in the relaxing of hair are disclosed herein. Hair that is damaged during a relaxing treatment with hydroxide-containing relaxing agents, can be treated with formulations containing one or more active agents. The active agent formulations can be applied simultaneously with the hair relaxing formulation, or optionally applied immediately following application of the relaxing formulation, to reduce damage and breakage. Use of the active agent formulation along with a relaxing treatment can be used to control the level of curl achieved or retained in the relaxed hair, as compared to the natural amount of curl in the untreated hair.
1. A kit comprising:
(a) a first formulation comprising one or more relaxing agents and having an alkaline pH, and
(b) a second formulation comprising an active agent, wherein the active agent has the following structure:
wherein
A, B, C, and D are reactive moieties containing one or more charges, and wherein each of A, B, C, and D independently contains a moiety selected from the group consisting of a vinyl sulfone, an acrylate group, a methacrylate group, a styrene group, an acryl amide group, a methacryl amide group, a maleate group, a fumarate group, and an itaconate group;
R is a linker that contains two or more charges, wherein the charges are opposite to the charges on the reactive moieties, wherein n=1-10, and wherein R is not a polymer, and
wherein the sum of the charges is zero;
wherein the reactive moieties are ionically bound to the linker; and
wherein each occurrence of p, q, r, and s is independently an integer from 0 to 25,
wherein the sum of p+q+r+s is equal to or greater than 2.
2. The kit of claim 1 , wherein the linker is a polyfunctional molecule, wherein the linker is optionally independently substituted with one or more substituents selected from the group consisting of hydrogen, halogen, cyano, alkoxy, alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocycloalkyl, heteroaryl, amine, hydroxy, formyl, acyl, carboxylic acid, —C(O)R 1 , —C(O)OR 1 , carboxylate, primary amide, secondary amide, —C(O)NR 1 R 2 , —NR 1 R 2 , —NR 1 S(O) 2 R 2 , —NR 1 C(O)R 2 , —S(O) 2 R 2 , —SR 1 , and —S(O) 2 NR 1 R 2 , sulfinyl group, and sulfonyl group; wherein R 1 and R 2 may each independently be hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycloalkyl, or heteroaryl; wherein each of R 1 and R 2 is optionally independently substituted with one or more substituents selected from the group consisting of halogen, hydroxyl, cyano, nitro, amino, alkylamino, dialkylamino, alkyl optionally substituted with one or more halogen or alkoxy or aryloxy, aryl optionally substituted with one or more halogen or alkoxy or alkyl or trihaloalkyl, heterocycloalkyl optionally substituted with aryl or heteroaryl or ═O or alkyl optionally substituted with hydroxyl, cycloalkyl optionally substituted with hydroxyl, heteroaryl optionally substituted with one or more halogen or alkoxy or alkyl or trihaloalkyl, haloalkyl, hydroxyalkyl, carboxy, alkoxy, aryloxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, and dialkylaminocarbonyl.
3. The kit of claim 1 , wherein the linker is a polyfunctional molecule, and wherein the linker is an alkoxy, an ether, an alkyl, an alkenyl, a cycloalkyl, a cycloalkenyl, an aryl, a heterocycloalkyl, a heteroaryl, or an amine.
4. The kit of claim 1 , wherein the one or more relaxing agents are alkali metal containing hydroxides selected from the group consisting of sodium hydroxide, lithium hydroxide, and potassium hydroxide.
5. The kit of claim 1 , wherein the second formulation is in the form of a liquid.
6. The kit of claim 1 , wherein the second formulation is in the form of a cream.
7. The kit of claim 1 , wherein the second formulation is in the form of a lotion.
8. The kit of claim 1 , wherein the second formulation is in the form of a gel.
9. The kit of claim 1 , wherein the active agent is:
10. The kit of claim 1 , wherein the second formulation further comprises one or more cosmetically acceptable excipients selected from the group consisting of water, surfactants, vitamins, natural extracts, preservatives, antioxidants, chelating agents, proteins, amino acids, humectants, fragrances, emollients, penetrants, thickeners, viscosity modifiers, hair fixatives, film formers, emulsifiers, opacifying agents, propellants, liquid vehicles, carriers, salts, pH adjusting agents, neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, and combinations thereof.
11. The kit of claim 10 , wherein the cosmetically acceptable excipient is present in an amount ranging from about 40 wt % to about 99 wt % of the second formulation.
12. The kit of claim 1 , wherein the active agent is present in an amount ranging from about 1 wt % to about 25 wt % of the second formulation.
13. The kit of claim 12 , wherein the active agent is present in an amount ranging from about 1 wt % to about 15 wt % of the second formulation.
14. The kit of claim 12 , wherein the active agent is present in an amount ranging from about 1 wt % to about 10 wt % of the second formulation.
15. The kit of claim 12 , wherein the active agent is present in an amount ranging from about 1 wt % to about 5 wt % of the second formulation.
16. The kit of claim 1 , further comprising instructions for use, a mixing container, an odor eliminator, or a combination thereof.
17. The kit of claim 1 , wherein the second formulation is provided as two or more separate ingredients.
18. The kit of claim 17 , wherein the binding agent is provided as a dry powder in a sealed package and a cosmetically acceptable excipient is provided in a vial or other container.