IP Library Granted Patent US 11,653,841
Granted Patent B2
US 11,653,841 · App. 16/573,011 · Granted May 23, 2023

MAP estimation on VAD patients

Inventors: Carlos Reyes (Davie, FL); Fernando Casas (Miami Lakes, FL)
Assignee: HeartWare, Inc.
A61B5/02108A61B5/746A61M60/178A61M60/232A61M60/411A61M60/523A61M60/531A61M60/538A61M60/585A61M2205/04A61M2205/18A61M2205/3334
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Quick Facts
Patent No.
US 11,653,841
App. No.
16/573,011
Granted
May 23, 2023
Kind
B2
Abstract

A method of determining a mean arterial pressure index of a patient having an implantable blood pump including determining a pump speed and a pump flow value; analyzing the pump speed and the pump flow value to a pump loss constant value; determining a graft hydraulic resistance value during a systolic phase of a cardiac cycle based on the analysis of the pump speed and the pump flow value to the pump loss constant value; determining a mean arterial pressure index during a diastolic phase of the cardiac cycle based on the determined graft hydraulic resistance value; comparing the mean arterial pressure index of the patient to a mean arterial pressure index range; and generating an alert when the mean arterial pressure index varies with respect to a mean arterial pressure index range.

Claims (36)

1. A method of determining a mean arterial pressure index of a patient having a blood pump, the method comprising:

determining a graft hydraulic resistance value during a systolic phase of a cardiac cycle of the patient based on a pump speed, a pump flow value, and a pump loss constant value of the blood pump;

calculating the mean arterial pressure index during a diastolic phase of the cardiac cycle based on the graft hydraulic resistance value; and

adjusting a pump parameter of the blood pump in response to the mean arterial pressure index deviating from a mean arterial pressure index range.

2. The method of claim 1 , further comprising determining a ventricular pressure of the patient and analyzing the determined ventricular pressure of the patient relative to the graft hydraulic resistance value.

3. The method of claim 1 , wherein the graft hydraulic resistance value is external to the blood pump.

4. The method of claim 1 , further comprising generating an alert in response to the mean arterial pressure index deviating from the mean arterial pressure index range.

5. A system comprising:

an implantable blood pump including an impeller; and

a controller coupled to the blood pump and including a control circuit configured to:

determine a graft hydraulic resistance value during a systolic phase of a cardiac cycle of a patient based on a pump speed, a pump flow value, and a pump loss constant value of a blood pump;

calculate the mean arterial pressure index during a diastolic phase of the cardiac cycle based on the graft hydraulic resistance value; and

perform a pump parameter adjustment related to the implantable blood pump in response to the mean arterial pressure index deviating from a mean arterial pressure index range.

6. The system of claim 5 , wherein the graft hydraulic resistance value is external to the blood pump.

7. The system of claim 5 , wherein the control circuit is configured to generate an alert in response to the mean arterial pressure index deviating from the mean arterial pressure index range.

8. The system of claim 5 , wherein the control circuit is configured to perform a second pump parameter adjustment in response to the mean arterial pressure index deviating from the mean arterial pressure index range, the second pump parameter adjustment being different than the pump parameter adjustment.

9. The system of claim 5 , wherein to determine the graft hydraulic resistance value, the control circuit is configured to divide the pump speed by the pump flow value and subtract the pump loss constant value.

10. The system of claim 5 , wherein the control circuit is configured to determine a ventricular pressure of the patient and analyze the determined ventricular pressure of the patient relative to the graft hydraulic resistance value.

11. The system of claim 10 , wherein the control circuit is configured to determine the ventricular pressure of the patient using at least one of a pressure sensor or a ventricular pressure waveform estimation.

12. The system of claim 5 , wherein the control circuit is configured to execute a treatment response in response to the mean arterial pressure index deviating from the mean arterial pressure index range.

13. The system of claim 5 , wherein the pump loss constant value is associated with a loss in pump pressure.

14. A system comprising:

a blood pump including an impeller;

a controller including a control circuit configured to:

determine a pump speed and a pump flow value of the blood pump;

analyze the pump speed and the pump flow value at least in part with respect to a pump loss constant value;

determine a graft hydraulic resistance value during a systolic phase of a cardiac cycle of a patient based on the analysis of the pump speed and the pump flow value with respect to the pump loss constant value;

determine a mean arterial pressure index during a diastolic phase of the cardiac cycle based on the determined graft hydraulic resistance value;

compare the mean arterial pressure index of the patient to a mean arterial pressure index range; and

generate an alert in response to determining the mean arterial pressure index varies with respect to a mean arterial pressure index range.

15. The system of claim 14 , wherein to analyze the pump speed and the pump flow value to the pump loss constant value, the control circuit is configured to divide the pump speed by the pump flow value and subtract the pump loss constant value.

16. The system of claim 14 , wherein the control circuit is configured to determine a ventricular pressure of the patient and analyze the determined ventricular pressure of the patient relative to the graft hydraulic resistance value, the pump speed, the pump flow value, and the pump loss constant value.

17. The system of claim 16 , wherein the control circuit is configured to determine the ventricular pressure of the patient using a pressure sensor.

18. The system of claim 16 , wherein the control circuit is configured to determine the ventricular pressure of the patient based on a ventricular pressure waveform estimation.

19. The system of claim 14 , wherein the pump loss constant value is associated with a pressure loss of the blood pump.

20. The system of claim 14 , wherein the control circuit is configured to establish the mean arterial pressure index range based on the mean arterial pressure index measured during a plurality of time periods.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2024
From: HEARTWARE, INC.
To: BOSTON SCIENTIFIC SCIMED, INC.
Reel/Frame 069431/0704 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2020
From: REYES, CARLOS; CASAS, FERNANDO
To: HEARTWARE, INC.
Reel/Frame 051654/0050 →
Continuity (2)
Provisional Application 62737244 · Sep 27, 2018
Related Publication 20200101209A1 · Apr 2, 2020
Cited By (17)
US 12,194,287 US 12,201,821 US 12,222,267 US 12,257,424 US 12,310,708 US 12,311,160 US 12,324,906 US 12,377,256 US 12,478,267 US 12,491,357 US 12,502,524 US 12,508,418 US 12,569,671 US 12,667,714 US 12,702,816 US 12,702,821 US 12,741,135