Granted Patent B2

US 10,781,340 · App. 16/582,624 · Granted Sep 22, 2020

Inventors: Yongxing Qiu (Suwanee, GA); John Dallas Pruitt (Suwanee, GA); Sibichen J. Thekveli (Alpharetta, GA); Robert Carey Tucker (Suwanee, GA); Jared Nelson (Buford, GA)

Assignee: Alcon Inc.

C09D177/06B29D11/00067C08G77/388C08J5/00C08J7/042C08L83/04C09D5/1637C09D5/1681C09D133/02C09D133/14C09D133/26C09D171/02G02B1/043G02B1/10G02B1/18G02C7/049C08J2383/04C08J2383/08C08J2433/02C08J2433/26C08J2487/00G02C2202/06G02C2202/16

Abstract

Claims (102)

1. A silicone hydrogel contact lens, comprising:

a silicone hydrogel bulk material covered with an outer surface hydrogel layer, wherein the silicone hydrogel bulk material comprises (i) repeating units derived from a silicone-containing vinylic monomer, a silicone-containing vinylic macromer, a silicone-containing prepolymer or combinations thereof and (ii) repeating units derived from a hydrophilic vinylic monomer, and has a first water content, designated as WC SiHy , of from about 10% to about 70% by weight,

wherein the outer surface hydrogel layer comprises a crosslinked polymeric material which comprises poly(ethylene glycol) chains which are designated as PEG chains, and wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 5% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state,

wherein the silicone hydrogel contact lens, when being fully hydrated, has: an oxygen transmissibility of at least about 40 barrers/mm; an elastic modulus of from about 0.3 MPa to about 1.8 MPa; and an averaged water contact angle of about 80 degrees or less.

2. The silicone hydrogel contact lens of claim 1 , wherein the PEG chains are derived from at least one member selected from the group consisting of:

PEG-NH 2 ; H 2 N-PEG-NH 2 ; H 2 N-PEG-COOH; a multi-arm PEG with one or more amino groups; a PEG dendrimer with one or more amino groups; and combinations thereof.

3. The silicone hydrogel contact lens of claim 2 , wherein the silicone hydrogel bulk material comprises repeating units derived from a polysiloxane vinylic monomer, a polysiloxane vinylic macromer, or combinations thereof.

4. The silicone hydrogel contact lens of claim 3 , wherein the polysiloxane vinylic monomer or macromer is a monomethacrylated or monoacrylated polydimethylsiloxane, a vinyl carbonate-terminated polydimethylsiloxane, a vinyl carbamate-terminated polydimethylsiloxane, a vinyl terminated polydimethylsiloxane, a methacrylamide-terminated polydimethylsiloxane, an acrylamide-terminated polydimethylsiloxane, an acrylate-terminated polydimethylsiloxane, a methacrylate-terminated polydimethylsiloxane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane; N,N,N′,N′-tetrakis(3-methacryloxy-2-hydroxypropyl)-alpha,omega-bis-3-aminopropyl-polydimethylsiloxane, a polysiloxanylalkyl (meth)acrylic monomer, or a reaction product of glycidyl methacrylate with amino-functional polydimethylsiloxane.

5. The silicone hydrogel contact lens of claim 3 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, and mixtures thereof.

6. The silicone hydrogel contact lens of claim 5 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

7. The silicone hydrogel contact lens of claim 3 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

8. The silicone hydrogel contact lens of claim 7 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

9. The silicone hydrogel contact lens of claim 1 , wherein the PEG chains are derived from at least one member selected from the group consisting of:

PEG-COOH; HOOC-PEG-COOH; a multi-arm PEG with one or more carboxyl groups; a PEG dendrimer with one or more carboxyl groups; and combinations thereof.

10. The silicone hydrogel contact lens of claim 9 , wherein the silicone hydrogel bulk material comprises repeating units derived from a polysiloxane vinylic monomer, a polysiloxane vinylic macromer, or combinations thereof.

11. The silicone hydrogel contact lens of claim 10 , wherein the polysiloxane vinylic monomer or macromer is a monomethacrylated or monoacrylated polydimethylsiloxane, a vinyl carbonate-terminated polydimethylsiloxane, a vinyl carbamate-terminated polydimethylsiloxane, a vinyl terminated polydimethylsiloxane, a methacrylamide-terminated polydimethylsiloxane, an acrylamide-terminated polydimethylsiloxane, an acrylate-terminated polydimethylsiloxane, a methacrylate-terminated polydimethylsiloxane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane; N,N,N′,N′-tetrakis(3-methacryloxy-2-hydroxypropyl)-alpha,omega-bis-3-aminopropyl-polydimethylsiloxane, a polysiloxanylalkyl (meth)acrylic monomer, or a reaction product of glycidyl methacrylate with amino-functional polydimethylsiloxane.

12. The silicone hydrogel contact lens of claim 10 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, and mixtures thereof.

13. The silicone hydrogel contact lens of claim 12 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

14. The silicone hydrogel contact lens of claim 10 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

15. The silicone hydrogel contact lens of claim 14 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

16. The silicone hydrogel contact lens of claim 1 , wherein the PEG chains are derived from at least one member selected from the group consisting of:

PEG-SH; HS-PEG-SH; HOOC-PEG-SH; H 2 N-PEG-SH; a multi-arm PEG with one or more thiol groups; a PEG dendrimer with one or more thiol groups; and combinations thereof.

17. The silicone hydrogel contact lens of claim 16 , wherein the silicone hydrogel bulk material comprises repeating units derived from a polysiloxane vinylic monomer, a polysiloxane vinylic macromer, or combinations thereof.

18. The silicone hydrogel contact lens of claim 17 , wherein the polysiloxane vinylic monomer or macromer is a monomethacrylated or monoacrylated polydimethylsiloxane, a vinyl carbonate-terminated polydimethylsiloxane, a vinyl carbamate-terminated polydimethylsiloxane, a vinyl terminated polydimethylsiloxane, a methacrylamide-terminated polydimethylsiloxane, an acrylamide-terminated polydimethylsiloxane, an acrylate-terminated polydimethylsiloxane, a methacrylate-terminated polydimethylsiloxane, bis-3-methacryloxy-2-hydroxypropyloxypropyl polydimethylsiloxane; N,N,N′,N′-tetrakis(3-methacryloxy-2-hydroxypropyl)-alpha,omega-bis-3-aminopropyl-polydimethylsiloxane, a polysiloxanylalkyl (meth)acrylic monomer, or a reaction product of glycidyl methacrylate with amino-functional polydimethylsiloxane.

19. The silicone hydrogel contact lens of claim 17 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, and mixtures thereof.

20. The silicone hydrogel contact lens of claim 19 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

21. The silicone hydrogel contact lens of claim 17 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

22. The silicone hydrogel contact lens of claim 21 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

23. The silicone hydrogel contact lens of claim 2 , wherein the silicone hydrogel bulk material comprises repeating units derived from a silicone-containing vinylic monomer selected from the group consisting of N-[tris(trimethylsiloxy)silylpropyl]-(meth)acrylamide, N-[tris(dimethylpropylsiloxy)-silylpropyl]-(meth)acrylamide, N-[tris(dimethylphenylsiloxy)silylpropyl] (meth)acrylamide, N-[tris(dimethylethylsiloxy)silylpropyl] (meth)acrylamide, N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl)-2- methyl acrylamide; N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl) acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl] acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)-2-methyl acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl) propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; 3-methacryloxy propylpentamethyldisiloxane, tris(trimethylsilyloxy)silylpropyl methacrylate (TRIS), (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane), (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, 3-methacryloxy-2-(2-hydroxyethoxy)-propyloxy)propylbis(trimethylsiloxy)methylsilane, N-2-methacryloxyethyl-O-(methyl-bis-trimethylsiloxy-3-propyl)silyl carbamate, 3-(trimethylsilyl)propylvinyl carbonate, 3-(vinyloxycarbonylthio)propyl-tris(trimethyl-siloxy)silane, 3-[tris(trimethylsiloxy)silyl]propylvinyl carbamate, 3-[tris(trimethylsiloxy)silyl] propyl allyl carbamate, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate, t-butyldimethyl-siloxyethyl vinyl carbonate; trimethylsilylethyl vinyl carbonate, trimethylsilylmethyl vinyl carbonate, and combinations therof.

24. The silicone hydrogel contact lens of claim 3 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

25. The silicone hydrogel contact lens of claim 23 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

26. The silicone hydrogel contact lens of claim 9 , wherein the silicone hydrogel bulk material comprises repeating units derived from a silicone-containing vinylic monomer selected from the group consisting of N-[tris(trimethylsiloxy)silylpropyl]-(meth)acrylamide, N-[tris(dimethylpropylsiloxy)-silylpropyl]-(meth)acrylamide, N-[tris(dimethylphenylsiloxy)silylpropyl] (meth)acrylamide, N-[tris(dimethylethylsiloxy)silylpropyl] (meth)acrylamide, N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl)-2- methyl acrylamide; N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl) acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl] acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)-2-methyl acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; 3-methacryloxy propylpentamethyldisiloxane, tris(trimethylsilyloxy)silylpropyl methacrylate (TRIS), (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane), (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, 3-methacryloxy-2-(2-hydroxyethoxy)-propyloxy)propylbis(trimethylsiloxy)methylsilane, N-2-methacryloxyethyl-O-(methyl-bis-trimethylsiloxy-3-propyl)silyl carbamate, 3-(trimethylsilyl)propylvinyl carbonate, 3-(vinyloxycarbonylthio)propyl-tris(trimethyl-siloxy)silane, 3-[tris(trimethylsiloxy)silyl]propylvinyl carbamate, 3-[tris(trimethylsiloxy)silyl] propyl allyl carbamate, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate, t-butyldimethyl-siloxyethyl vinyl carbonate; trimethylsilylethyl vinyl carbonate, trimethylsilylmethyl vinyl carbonate, and combinations therof.

27. The silicone hydrogel contact lens of claim 26 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

28. The silicone hydrogel contact lens of claim 27 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

29. The silicone hydrogel contact lens of claim 16 , wherein the silicone hydrogel bulk material comprises repeating units derived from a silicone-containing vinylic monomer selected from the group consisting of N-[tris(trimethylsiloxy)silylpropyl]-(meth)acrylamide, N-[tris(dimethylpropylsiloxy)-silylpropyl]-(meth)acrylamide, N-[tris(dimethylphenylsiloxy)silylpropyl] (meth)acrylamide, N-[tris(dimethylethylsiloxy)silylpropyl] (meth)acrylamide, N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl)-2- methyl acrylamide; N-(2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl) acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl]- 2 -methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(bis(trimethylsilyloxy)methylsilyl)propyloxy)propyl] acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)-2-methyl acrylamide; N-(2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl)acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(tris(trimethylsilyloxy)silyl)propyloxy)propyl]acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl acrylamide; N-[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]-2-methyl acrylamide; N,N-bis[2-hydroxy-3-(3-(t-butyldimethylsilyl)propyloxy)propyl]acrylamide; 3-methacryloxy propylpentamethyldisiloxane, tris(trimethylsilyloxy)silylpropyl methacrylate (TRIS), (3-methacryloxy-2-hydroxypropyloxy)propylbis(trimethylsiloxy)methylsilane), (3-methacryloxy-2-hydroxypropyloxy)propyltris(trimethylsiloxy)silane, 3-methacryloxy-2-(2-hydroxyethoxy)-propyloxy)propylbis(trimethylsiloxy)methylsilane, N-2-methacryloxyethyl-O-(methyl-bis-trimethylsiloxy-3-propyl)silyl carbamate, 3-(trimethylsilyl)propylvinyl carbonate, 3-(vinyloxycarbonylthio)propyl-tris(trimethyl-siloxy)silane, 3-[tris(trimethylsiloxy)silyl]propylvinyl carbamate, 3-[tris(trimethylsiloxy)silyl] propyl allyl carbamate, 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate, t-butyldimethyl-siloxyethyl vinyl carbonate; trimethylsilylethyl vinyl carbonate, trimethylsilylmethyl vinyl carbonate, and combinations therof.

30. The silicone hydrogel contact lens of claim 29 , wherein the silicone hydrogel bulk material comprises repeating units derived from a hydrophilic vinylic monomer selected from the group consisting of N,N-dimethylacrylamide, N,N-dimethylmethacrylamide, 2-acrylamidoglycolic acid, 3-acryloylamino-1-propanol, N-hydroxyethyl acrylamide, N-[tris(hydroxymethyl)methyl]acrylamide, 2-hydroxyethylmethacrylate, 2-hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxypropyl methacrylate, trimethylammonium 2-hydroxy propylmethacrylate hydrochloride, aminopropyl methacrylate hydrochloride, dimethylaminoethyl methacrylate, glycerol methacrylate, allyl alcohol, a C 1 -C 4 -alkoxy polyethylene glycol (meth)acrylate having a weight average molecular weight of up to 1500, methacrylic acid, N-methyl-3-methylene-2-pyrrolidone, 1-ethyl-3-methylene-2-pyrrolidone, 1-methyl-5-methylene-2-pyrrolidone, 1-ethyl-5-methylene-2-pyrrolidone, 5-methyl-3-methylene-2-pyrrolidone, 5-ethyl-3-methylene-2-pyrrolidone, 1-n-propyl-3-methylene-2-pyrrolidone, 1-n-propyl-5-methylene-2-pyrrolidone, 1-isopropyl-3-methylene-2-pyrrolidone, 1-isopropyl-5-methylene-2-pyrrolidone, 1-n-butyl-3-methylene-2-pyrrolidone, 1-tert-butyl-3-methylene-2-pyrrolidone, N-vinyl-2-pyrrolidone, vinylpyridine, N-vinyl formamide, N-vinyl acetamide, N-vinyl isopropylamide, N-vinyl-N-methyl acetamide, N-vinyl caprolactam, and mixtures thereof.

31. The silicone hydrogel contact lens of claim 30 , wherein the silicone hydrogel bulk material comprises repeating units derived from a crosslinking agent selected from the group consisting of tetraethyleneglycol diacrylate, triethyleneglycol diacrylate, ethyleneglycol diacylate, diethyleneglycol diacrylate, tetraethyleneglycol dimethacrylate, triethyleneglycol dimethacrylate, ethyleneglycol dimethacylate, diethyleneglycol dimethacrylate, trimethylopropane trimethacrylate, pentaerythritol tetramethacrylate, bisphenol A dimethacrylate, vinyl methacrylate, ethylenediamine dimethyacrylamide, ethylenediamine diacrylamide, glycerol dimethacrylate, triallyl isocyanurate, triallyl cyanurate, allylmethacrylate, allylmethacrylate, 1,3-bis(methacrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, N,N′-methylenebisacrylamide, N,N′-methylenebismethacrylamide, N,N′-ethylenebisacrylamide, N,N′-ethylenebismethacrylamide,1,3-bis(N-methacrylamidopropyl)-1,1,3,3-tetrakis-(trimethylsiloxy)disiloxane, 1,3-bis(methacrylamidobutyl)-1,1,3,3-tetrakis(trimethylsiloxy)-disiloxane, 1,3-bis(acrylamidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, 1,3-bis(methacryloxyethylureidopropyl)-1,1,3,3-tetrakis(trimethylsiloxy)disiloxane, and combinations thereof.

32. The silicone hydrogel contact lens of claim 1 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

33. The silicone hydrogel contact lens of claim 32 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

34. The silicone hydrogel contact lens of claim 32 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

35. The silicone hydrogel contact lens of claim 34 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

36. The silicone hydrogel contact lens of claim 34 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

37. The silicone hydrogel contact lens of claim 6 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

38. The silicone hydrogel contact lens of claim 37 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

39. The silicone hydrogel contact lens of claim 37 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

40. The silicone hydrogel contact lens of claim 39 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

41. The silicone hydrogel contact lens of claim 39 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

42. The silicone hydrogel contact lens of claim 8 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

43. The silicone hydrogel contact lens of claim 42 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

44. The silicone hydrogel contact lens of claim 42 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

45. The silicone hydrogel contact lens of claim 44 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

46. The silicone hydrogel contact lens of claim 44 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

47. The silicone hydrogel contact lens of claim 13 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

48. The silicone hydrogel contact lens of claim 47 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

49. The silicone hydrogel contact lens of claim 47 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

50. The silicone hydrogel contact lens of claim 49 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

51. The silicone hydrogel contact lens of claim 49 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

52. The silicone hydrogel contact lens of claim 15 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

53. The silicone hydrogel contact lens of claim 52 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

54. The silicone hydrogel contact lens of claim 52 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

55. The silicone hydrogel contact lens of claim 54 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

56. The silicone hydrogel contact lens of claim 54 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

57. The silicone hydrogel contact lens of claim 20 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

58. The silicone hydrogel contact lens of claim 57 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

59. The silicone hydrogel contact lens of claim 57 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

60. The silicone hydrogel contact lens of claim 59 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

61. The silicone hydrogel contact lens of claim 59 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

62. The silicone hydrogel contact lens of claim 22 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

63. The silicone hydrogel contact lens of claim 62 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

64. The silicone hydrogel contact lens of claim 62 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

65. The silicone hydrogel contact lens of claim 64 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

66. The silicone hydrogel contact lens of claim 64 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

67. The silicone hydrogel contact lens of claim 25 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

68. The silicone hydrogel contact lens of claim 67 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

69. The silicone hydrogel contact lens of claim 67 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

70. The silicone hydrogel contact lens of claim 69 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

71. The silicone hydrogel contact lens of claim 69 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

72. The silicone hydrogel contact lens of claim 28 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

73. The silicone hydrogel contact lens of claim 72 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

74. The silicone hydrogel contact lens of claim 72 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

75. The silicone hydrogel contact lens of claim 74 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

76. The silicone hydrogel contact lens of claim 74 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

77. The silicone hydrogel contact lens of claim 31 , wherein the outer surface hydrogel layer has a second water content greater than 75% by weight.

78. The silicone hydrogel contact lens of claim 77 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

79. The silicone hydrogel contact lens of claim 77 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

80. The silicone hydrogel contact lens of claim 79 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

81. The silicone hydrogel contact lens of claim 79 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

82. The silicone hydrogel contact lens of claim 1 , wherein the outer surface hydrogel layer has a second water content which is at least about 1.3 folds of the first water content of the silicone hydrogel bulk material.

83. The silicone hydrogel contact lens of claim 82 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

84. The silicone hydrogel contact lens of claim 82 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

85. The silicone hydrogel contact lens of claim 84 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 pm.

86. The silicone hydrogel contact lens of claim 84 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

87. The silicone hydrogel contact lens of claim 1 , wherein the outer surface hydrogel layer has a second water content which is at least about 1.5 folds of the first water content of the silicone hydrogel bulk material.

88. The silicone hydrogel contact lens of claim 87 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

89. The silicone hydrogel contact lens of claim 87 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

90. The silicone hydrogel contact lens of claim 89 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

91. The silicone hydrogel contact lens of claim 89 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

92. The silicone hydrogel contact lens of claim 1 , wherein the outer surface hydrogel layer has a second water content which is at least about 2 folds of the first water content of the silicone hydrogel bulk material.

93. The silicone hydrogel contact lens of claim 92 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 4% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

94. The silicone hydrogel contact lens of claim 92 , wherein the silicone hydrogel contact lens has a silicon atomic percentage of about 3% or less of total elemental percentage as measured by XPS analysis of the silicone hydrogel contact lens in dried state.

95. The silicone hydrogel contact lens of claim 94 , wherein the outer surface hydrogel layer has a thickness of at least about 0.1 μm.

96. The silicone hydrogel contact lens of claim 94 , wherein the outer surface hydrogel layer has a thickness of from about 0.25 μm to about 15 μm.

Assignments (2)

Continuity (10)