IP Library › Patent Application 16586088

Patent Application

App. No. 16/586,088

Monoacylglycerol Lipase Modulators

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US None
App. No.: 16/586,088

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein R 1 , R 2 , R 2a , R 3 , R 3a , R 4 , and R 4a are defined herein.

Claims (662)

1 - 27 . (canceled)

28 . A compound, having the structure of Formula (II):

wherein

R 1 is C 1-4 alkyl;

R 2a is selected from the group consisting of:

(b) 6-Membered heteroaryl selected from the group consisting of:

(d) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

(e) Fused 6,6 heteroaryl selected from the group consisting of:

and

(f) Heterocycloalkyl selected from the group consisting of:

R 3a is selected from the group consisting of:

(g) Phenyl; or phenyl substituted with one, two, or three members each independently selected from the group consisting of: halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-6 haloalkyl;

(h) 5-Membered heteroaryl selected from the group consisting of:

(i) 6-Membered heteroaryl selected from the group consisting of:

(j) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

and

(k) Heterocycloalkyl selected from the group consisting of:

R e is selected from the group consisting of: OC 1-4 alkyl, OC 1-4 haloalkyl, (C═O)NHCH 3 , and 5-membered heteroaryl ring containing two or three nitrogen members, wherein the 5-membered heteroaryl ring is optionally substituted with one R f member;

R f is selected from the group consisting of: H, halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R g is selected from the group consisting of: OC 1-4 alkyl, OC 1-4 haloalkyl, CH 2 OCH 3 , CH 2 OH,

R h is selected from the group consisting of: H, C 1-4 alkyl, C 1-4 haloalkyl, and C 3-6 cycloalkyl;

R i is selected from the group consisting of: H, halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, C 3-6 cycloalkyl, and C 3-6 cycloalkyl substituted with one or two members independently selected from: F and CH 3 ;

R j is selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 haloalkyl;

R k is selected from the group consisting of: H, halo, OH, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R m is H or C 1-4 alkyl;

R n is selected from the group consisting of: H, halo and OC 1-4 alkyl;

R o is selected from the group consisting of: H, C 1-4 alkyl, and C 1-4 haloalkyl;

R p is selected from the group consisting of: H, C 1-4 alkyl, and OC 1-4 alkyl;

Y is CH or N; and

R 4a is selected from the group consisting of: CH 3 , CF 2 H, CF 3 , C 3-6 cycloalkyl, and phenyl;

and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof.

29 . A compound as claimed in claim 28 , wherein R 1 is CH 3 .

30 . A compound as claimed in claim 28 , wherein R 1 is CH 2 CH 3 .

31 . A compound as claimed in claim 28 , wherein R 2a is

32 . A compound as claimed in claim 28 , wherein R 2a is

where R e is

and R f is H, F, CH 3 , CF 3 , or OCH 3 .

33 . A compound as claimed in claim 28 , wherein R e is

34 . A compound as claimed in claim 28 , wherein R 2a is

35 . A compound as claimed in claim 28 , wherein R 2a is

36 . A compound as claimed in claim 28 , wherein R 2a is

37 . A compound as claimed in claim 28 , wherein R 2a is

38 . A compound as claimed in claim 28 , wherein R 2a is

39 . A compound as claimed in claim 28 , wherein R 2a is

40 . A compound as claimed in claim 28 , wherein R 2 is

41 . A compound as claimed in claim 28 , wherein R 2a is

42 . A compound as claimed in claim 28 , wherein R 2a is

43 . A compound as claimed in claim 28 , wherein R 2a is

44 . A compound as claimed in claim 28 , wherein R 2a is

45 . A compound as claimed in claim 28 , wherein R 2a is

46 . A compound as claimed in claim 28 , wherein R 2a is

47 . A compound as claimed in claim 28 , wherein R 2a is

48 . A compound as claimed in claim 28 , wherein R 2a is

49 . A compound as claimed in claim 28 , wherein R 2a is

50 . A compound as claimed in claim 28 , wherein R 2a is

51 . A compound as claimed in claim 28 , wherein R 2a is

52 . A compound as claimed in claim 28 , wherein R 2a is

53 . A compound as claimed in claim 28 , wherein R 2a is

54 . A compound as claimed in claim 28 , wherein R 2a is

55 . A compound as claimed in claim 28 , wherein R 2a is

56 . A compound as claimed in claim 28 , wherein R 2a is

57 . A compound as claimed in claim 28 , wherein R 2a is

58 . A compound as claimed in claim 28 , wherein R 2a is

59 . A compound as claimed in claim 28 , wherein R 2a is

60 . A compound as claimed in claim 28 , wherein R 2a is

61 . A compound as claimed in claim 28 , wherein R 2a is

62 . A compound as claimed in claim 28 , wherein R 2a is

63 . A compound as claimed in claim 28 , wherein R 2a is

64 . A compound as claimed in claim 28 , wherein R 2a is

65 . A compound as claimed in claim 28 , wherein R 3a is Phenyl; or phenyl substituted with one member selected from the group consisting of: F, Cl, OCH 3 , OCH 2 CH 3 , OCH(CH 3 ) 2 , OCHF 2 , CF 3 , CF 2 CH 3 , OCF 2 H, and OCF 3 .

66 . A compound as claimed in claim 28 , wherein R 3a is phenyl substituted with two or three members independently selected from the group consisting of: F, Cl, CH 3 , CF 2 H, OCF 2 H and OCH 3 .

67 . A compound as claimed in claim 28 , wherein R 3a is 3,5-difluorophenyl, 3,5-dichlorophenyl, 3-chloro-5-fluorophenyl, 3-fluoro-5-methoxyphenyl, 3-chloro-4-methoxyphenyl, 3-fluoro-4-methoxyphenyl, or 3,4,5-trifluorophenyl.

68 . A compound as claimed in claim 28 , wherein R 3a is

69 . A compound as claimed in claim 28 , wherein R 3a is

70 . A compound as claimed in claim 28 , wherein R 4a is CH 3 .

71 . A compound as claimed in claim 28 , wherein R 4a is CF 3 .

72 . A compound as claimed in claim 28 , wherein R 4a is CF 2 H.

73 . A compound as claimed in claim 28 , wherein R 4a is phenyl.

74 - 82 . (canceled)

83 . A compound selected from the group consisting of:

(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(5-methylfuran-2-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(pyridin-3-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(5-Fluoropyridin-3-yl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(2,7-Dimethyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(2,7-Dimethyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(7-Methyl-2,3-diphenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(7-Methyl-2,3-diphenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(7-Methyl-2,3-diphenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(3-Chloro-5-(trifluoromethoxy)phenyl)(3-(3-chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-phenyl-1H-1,2,4-triazol-3-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-ethyl-1-(2-fluorophenyl)-1H-1,2,4-triazol-3-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(4-(hydroxymethyl)pyridin-2-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-(methoxymethyl)pyridin-3-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(6-isopropoxypyridin-3-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-isopropoxypyridin-3-yl)methanone;

(S)-Benzo[d][1,3]dioxol-4-yl(3-(3-chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-6-(3-(3-Chlorophenyl)-2,7-dimethyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-6-carbonyl)benzo[d]oxazol-2(3H)-one;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methylbenzo[d]oxazol-6-yl)methanone;

(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-6-yl)methanone;

(R)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-6-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-6-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-2-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1H-pyrrolo[2,3-b]pyridin-6-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1,5-naphthyridin-2-yl)methanone;

(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(R)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(8-Bromoquinoxalin-6-yl)(3-(3-chlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(7-Ethyl-3-(3-fluorophenyl)-2-methyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

[(7S)-3-(3,5-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(2-fluoroethoxy)phenyl]methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(4-(2-fluoroethoxy)phenyl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-(2-fluoroethoxy)phenyl)methanone;

(S)-[3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(2-fluoranylethoxy)phenyl]methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-fluoro-3-(2-fluoroethoxy)phenyl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-fluoro-5-(2-fluoroethoxy)phenyl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-fluoro-5-(2-fluoroethoxy)phenyl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(4-fluoro-3-(2-fluoroethoxy)phenyl)methanone;

[2-Chloro-3-(2-fluoroethoxy)phenyl]-[(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[2-chloro-5-(2-fluoroethoxy)phenyl]-[(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone4-Isopropyl-6-piperazin-1-yl-pyrimidin-2-ylamine;

(S)-(2-(2H-1,2,3-Triazol-2-yl)phenyl)(3-(3,5-difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-phenyl-1H-1,2,4-triazol-3-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-ethyl-1-phenyl-1H-1,2,4-triazol-3-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-(2-fluoroethyl)-1H-indol-4-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-(2-(fluoro- 18 F)ethyl)-1H-indol-5-yl);

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-(2-fluoroethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-6-yl)methanone;

(R)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-b]pyridin-6-yl)methanone;

(2-(Difluoromethyl)-3-(3,5-difluorophenyl)-7-methyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(3-(3,5-Difluorophenyl)-7-methyl-2-(trifluoromethyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(3-(3,5-Difluorophenyl)-7-methyl-2-(methyl-d3)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(isoquinolin-3-yl)methanone;

(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(isoquinolin-7-yl)methanone;

(4-Bromoquinolin-6-yl)(3-(3,5-difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(5-Chloroquinolin-6-yl)(3-(3,5-difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(8-(trifluoromethyl)quinolin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-(trifluoromethyl)quinolin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-(2-fluoroethoxy)quinolin-6-yl)methanone;

(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(R)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1,5-naphthyridin-2-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(7-fluoroquinoxalin-6-yl)methanone;

(S)-(3-(3,5-Dichlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methylbenzo[d]oxazol-6-yl)methanone;

(S)-(3-(3,5-Dichlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

(S)-(3-(3,5-Dichlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(3-(3,5-Dichlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3,5-Dichlorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methylquinoxalin-6-yl)methanone;

(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(R)-(3-(3-Chloro-5-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Chloro-4-methylphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Fluoro-5-(trifluoromethyl)phenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Fluoro-4-methoxyphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Fluoro-5-methoxyphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3-Fluoro-5-methoxyphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(7-fluoroquinoxalin-6-yl)methanone;

(S)-(3-(3-Chloro-4-methoxyphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(4-(Difluoromethoxy)-3-fluorophenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(3-(3,5-Difluoro-4-methylphenyl)-2,7-dimethyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(2-Chloro-3-methoxyphenyl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(3-Chloro-5-methoxyphenyl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-fluoro-2-(1H-pyrazol-1-yl)phenyl)methanone;

(S)-(3-(1H-1,2,4-Triazol-1-yl)phenyl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(3-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(4-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methanone;

(S)-(1-(tert-Butyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-methoxy-1-methyl-1H-pyrazol-3-yl)methanone;

(S)-(5-Cyclopropyl-1-methyl-1H-pyrazol-4-yl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-ethyl-1-phenyl-1H-1,2,4-triazol-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-methoxypyridin-3-yl)methanone;

(S)-6-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-6-carbonyl)-4-methyl-2H-benzo[b][1,4]oxazin-3 (4H)-one;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1H-indol-7-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-indol-7-yl)methanone;

(S)-(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-indol-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1H-indazol-7-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazol[3,4-c]pyridin-6-yl)(1-methyl-1H-indazol-7-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(7-methyl-1H-indazol-5-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-indazol-5-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(imidazo[1,5-a]pyridin-8-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(imidazo[1,2-a]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(furo[3,2-c]pyridin-4-yl)methanone;

(S)-Benzo[d]isoxazol-3-yl(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1H-pyrrolo[3,2-c]pyridin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[3,2-c]pyridin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1H-pyrrolo[3,2-c]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[3,2-c]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-2-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazol[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-c]pyridin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(pyrazolo[1,5-a]pyridin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(pyrazolo[1,5-a]pyridin-5-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(pyrazolo[1,5-a]pyrazin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone;

(S)-(2-(Difluoromethyl)-7-methyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(2-(Difluoromethyl)-7-methyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(R)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-8-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(isoquinolin-1-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(8-fluoroquinolin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methylquinolin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methoxyquinolin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(8-fluoro-2-methylquinolin-4-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(2-methylquinoxalin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1,5-naphthyridin-2-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1,5-naphthyridin-3-yl)methanone;

(S)-(2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(, 6-naphthyridin-8-yl)methanone;

(S)-(2,7-Dimethyl-3-(5-(trifluoromethyl)furan-2-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(S)-(2,7-Dimethyl-3-(5-(trifluoromethyl)pyridin-3-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinoxalin-6-yl)methanone;

(2,7-Dimethyl-3-(1-methyl-1H-indol-4-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(2,7-Dimethyl-3-(1-methyl-1H-indol-2-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(2,7-Dimethyl-3-(1-methyl-1H-indol-3-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[34-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(2,7-Dimethyl-3-(1-methyl-1H-indol-5-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone; and

(2,7-Dimethyl-3-(1-methyl-1H-indol-7-yl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(quinolin-6-yl)methanone;

(S)-(3-(3,5-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(2-fluoranylethoxy)-2-fluoro-phenyl]methanone;

[2-Chloro-3-(2-fluoranylethoxy)phenyl]-[(7S)-3-(3,5-difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(S)-[3-(3,5-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(2-fluoranylethoxy)-5-fluoro-phenyl]methanone;

(3-Methoxyphenyl)-[(7S)-7-methyl-2,3-diphenyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-(3-Fluoro-5-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxyphenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxyphenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxyphenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxyphenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(trifluoromethoxy)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(trifluoromethoxy)phenyl]methanone;

[4-(Difluoromethoxy)phenyl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-fluoro-4-methoxy-phenyl)methanone;

3-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-N-methyl-benzamide;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-imidazol-1-ylphenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(1H-pyrazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-(1H-pyrazol-5-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1H-pyrazol-3-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methoxy-3-(1-methylpyrazol-3-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1H-pyrazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1-methylpyrazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-5-(1-methylpyrazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(4-fluoropyrazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(3-methyl-1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methoxy-5-(1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-6-(1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-fluoro-2-(1,2,4-triazol-1-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-[3-(trifluoromethyl)-1,2,4-triazol-1-yl]phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-5-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methyl-5-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(triazol-2-yl)-5-(trifluoromethyl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-methoxy-2-(triazol-2-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-fluoro-3-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-fluoro-5-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methyl-5-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methyl-3-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)-4-(trifluoromethyl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1,2,4-triazol-4-yl)-5-(trifluoromethyl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[4-methoxy-3-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methoxy-5-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(1,2,4-triazol-4-yl)phenyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-3-methyl-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxy-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(methoxymethyl)-3-pyridyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-isopropoxy-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-2-methyl-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxy-3-methyl-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-2-methyl-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxy-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-6-methyl-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxy-4-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-4-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxy-4-methyl-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-2-methoxy-4-pyridyl)methanone;

(3-Chloro-2-methoxy-4-pyridyl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(3-Chloro-4-methoxy-2-pyridyl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-pyrazol-1-yl-3-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[6-methyl-3-(triazol-2-yl)-2-pyridyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-pyrazol-1-yl-2-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methyl-1-phenyl-1,2,4-triazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(4-fluorophenyl)-5-methyl-1,2,4-triazol-3-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(2-pyridyl)-1,2,4-triazol-3-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(3-fluoro-2-pyridyl)-1,2,4-triazol-3-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(2-pyridyl)-2-thienyl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxypyrazin-2-yl)methanone;

(1,5-Dimethylpyrazol-4-yl)-[(7S)-3-(3-fluoro-5-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-isopropyl-1-methyl-pyrazol-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(trifluoromethyl)pyrazol-4-yl]methanone;

[5-(Difluoromethyl)-1-methyl-pyrazol-4-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(1-Cyclopropylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[1-Cyclopropyl-3-(trifluoromethyl)pyrazol-4-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(5-Cyclobutyl-1-methyl-pyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-methyl-5-(1-methylcyclopropyl)pyrazol-4-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(1-fluorocyclopropyl)-1-methyl-pyrazol-4-yl]methanone;

(5-(2,2-Difluorocyclopropyl)-1-methyl-1H-pyrazol-4-yl)((S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-4,5-dihydro-2H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(5-((R*)-2,2-difluorocyclopropyl)-1-methyl-1H-pyrazol-4-yl)((S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(5-((S*)-2,2-Difluorocyclopropyl)-1-methyl-1H-pyrazol-4-yl)((S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

((S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(cis-5-(2-fluorocyclopropyl)-1-methyl-1H-pyrazol-4-yl)methanone;

((S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(trans-5-(2-fluorocyclopropyl)-1-methyl-1H-pyrazol-4-yl)methanone;

((S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(1-methyl-cis-5-(2-methylcyclopropyl)-1H-pyrazol-4-yl)methanone;

(S*)-(2-(Bicyclo[1.1.1]pentan-1-yl)-7-methyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl)methanone;

(1,3-Dimethylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone;

(1,5-Dimethylpyrazol-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[1-Cyclopropyl-5-(trifluoromethyl)pyrazol-4-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-methyl-3-(1-methylcyclopropyl)pyrazol-4-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(1-fluorocyclopropyl)-1-methyl-pyrazol-4-yl]methanone;

(R)-(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl) (7-methyl-2,3-diphenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl) methanone;

(S)-(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl) (7-methyl-2,3-diphenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone;

(1,2-Dimethylpyrrol-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(4,5-Dimethylisoxazol-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indol-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-1H-indol-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1-methyl-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-fluoro-1H-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-1H-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-1H-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methyl-1H-indol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-indazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-fluoro-1H-indazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-1H-indazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-indazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylindazol-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylbenzimidazol-4-yl)methanone;

1H-Benzotriazol-4-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-b]pyridin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1-methyl-pyrrolo[2,3-b]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl] methanone;

[(7S)-3-(3,5-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[1-(2-fluoranylethyl)pyrrolo[2,3-b]pyridin-4-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrrolo[2,3-c]pyridin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoropyrazolo[1,5-a]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoropyrazolo[1,5-a]pyridin-5-yl)methanone;

(3-Bromopyrazolo[1,5-a]pyridin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyrazin-6-yl]-(3-methylpyrazolo[1,5-a]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyridin-3-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylpyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoropyrazolo[1,5-a]pyridin-3-yl)methanone;

(2-Cyclopropyl-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrazolo[1,5-a] pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methoxypyrazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazol[3,4-c]pyridin-6-yl]-imidazo[1,2-a]pyridin-6-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-a]pyridin-8-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoroimidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-5-yl)methanone;

[(7S)-3-(3-Chloro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a] pyridin-3-yl) methanone;

[(7S)-3-(3-Fluoro-5-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a] pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,2-a]pyridin-2-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylimidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylimidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylimidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-fluoro-2-methyl-imidazo[1,2-a]pyridin-3-yl)methanone;

(2,8-Dimethylimidazo[1,2-a] pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(2,7-Dimethylimidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(2,6-Dimethylimidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-(3-Chloro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2-methyl-imidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2-methyl-imidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2,8-dimethyl-imidazo[1,2-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-fluoro-2,7-dimethyl-imidazo[1,2-a]pyridin-3-yl)methanone;

(6,8-Difluoro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methoxy-2-methyl-imidazo[1,2-a]pyridin-3-yl)methanone;

[2-(Difluoromethyl)imidazo[1,2-a]pyridin-3-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[2-(trifluoromethyl) imidazo[1,2-a]pyridin-3-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[5-methyl-2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrrolo[1,2-a] pyrazin-1-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrrolo[1,2-a]pyrazin-8-yl-methanone;

(2,4-Dimethylpyrrolo[1,2-a] pyrimidin-8-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl] methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a]pyridin-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylimidazo[1,5-a]pyridin-1-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,5-a]pyridin-1-yl-methanone;

(3-Cyclopropylimidazo[1,5-a]pyridin-1-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-b]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-b]pyridin-5-yl)methanone;

(1,6-Dimethylpyrazolo[3,4-b]pyridin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(1,3-Dimethylpyrazolo[3,4-b]pyridin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[3,4-c]pyridin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-c]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-c]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[3,4-c]pyridin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-c]pyridin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-c]pyridin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-c]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1H-pyrazolo[4,3-b]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-([1,2,4]triazolo[4,3-a]pyridin-6-yl)methanone;

[3-(Difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(triazolo[1,5-a]pyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-b]pyridazin-3-yl) methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methylpyrazolo[1,5-b]pyridazin-3-yl) methanone;

(2-Cyclopropyl-4-methyl-pyrazolo[1,5-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(2-Cyclopropyl-5-methyl-pyrazolo[1,5-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(2,4-Dimethylpyrazolo[1,5-a] pyrazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl] methanone;

(2-Cyclopropyl-4-methyl-pyrazolo[1,5-a]pyrazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrazolo[1,5-a]pyrimidin-3-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylpyrazolo[1,5-a]pyrimidin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrazolo[1,5-a] pyrimidin-3-yl) methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-b]pyridazin-6-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-b]pyridazin-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-imidazo[1,2-b]pyridazin-3-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-b]pyridazin-3-yl)methanone;

(2,8-Dimethylimidazo[1,2-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(2,7-Dimethylimidazo[1,2-b]pyridazin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl] methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylimidazo[1,2-a]pyrimidin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2,5,8-trimethylimidazo[1,2-a]pyrazin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-methylimidazo[1,5-a]pyrimidin-8-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a]pyrimidin-8-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylimidazo[1,5-a] pyrazin-1-yl) methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-(trifluoromethyl) imidazo[1,5-a] pyrazin-1-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)methanone;

[(7S)-3-(3-Fluoro-5-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrrolo[2,3-d] pyrimidin-4-yl) methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylpyrrolo[2,3-d]pyrimidin-4-yl)methanone;

(5,7-Dimethylpyrrolo[2,3-d] pyrimidin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl] methanone;

[(7S)-2,7-Dimethyl-3-[3-(trifluoromethyl) phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

(6,7-Dimethylpyrrolo[2,3-d] pyrimidin-4-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7H-purin-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(7-methylquinoxalin-6-yl) methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methylquinoxalin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methylquinoxalin-5-yl)methanone;

(2,3-Dimethylquinoxalin-6-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinoxalin-2-yl-methanone;

Cinnolin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-6-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-7-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoroquinazolin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-quinazolin-4-yl-methanone;

(2-Deuterioquinoxalin-6-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-pyrido[4,3-d]pyrimidin-5-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,5-naphthyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,6-naphthyridin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-1,6-naphthyridin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,6-naphthyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,7-naphthyridin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,8-naphthyridin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,8-naphthyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(o-tolyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[2-(trifluoromethyl)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[4-(trifluoromethyl)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3-Methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2-Methoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(4-Ethoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3-Isopropoxyphenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-[3-(Difluoromethoxy)phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[4-(trifluoromethoxy)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[3-(trifluoromethoxy)phenyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2,4-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2,3-Difluorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(4-Chloro-3-fluoro-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3-Chloro-4-fluoro-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2-Chloro-4-fluoro-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3,4-Dichlorophenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(5-Fluoro-2-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(4-Fluoro-3-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2-Fluoro-3-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3-Fluoro-5-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(4-Methoxy-3-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(3-Chloro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(4-Chloro-2,3-difluoro-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(2,3,4-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-oxidoquinolin-1-ium-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-hydroxy-6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-hydroxy-6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(6-methyl-3-pyridyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(2-methyl-4-pyridyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-[6-(Difluoromethyl)-3-pyridyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[6-(trifluoromethyl)-3-pyridyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[2-(trifluoromethyl)-4-pyridyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-[5-(trifluoromethyl)-3-thienyl]-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(6-Methoxy-3-pyridyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2-Methoxy-4-pyridyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-[6-(Difluoromethoxy)-3-pyridyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-[5-(Difluoromethoxy)-3-pyridyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(6-Methoxy-5-methyl-3-pyridyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-[6-Methoxy-5-(trifluoromethyl)-3-pyridyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(1H-Indol-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(Benzofuran-6-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(Benzofuran-5-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(Benzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(Benzofuran-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(5-Fluorobenzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(1,3-Benzothiazol-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2,1,3-Benzoxadiazol-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2,3-Dihydrobenzofuran-7-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(1,3-Benzodioxol-5-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(1,3-Benzodioxol-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-3-(2,2-Difluoro-1,3-benzodioxol-4-yl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-isoquinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(6-isoquinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5-fluoro-3-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-fluoro-4-isoquinolyl)methanone;

(4-Bromo-6-quinolyl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methyl-6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methyl-6-quinolyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(8-methoxy-4-quinolyl)methanone;

5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)methanone;

6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2,6,6-trimethyl-4,7-dihydropyrazolo[5,1-c][1,4]oxazin-3-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3,6,6-trimethyl-4,7-dihydropyrazolo[5,1-c][1,4]oxazin-2-yl)methanone;

((S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-4,5-dihydro-2H-pyrazolo[3,4-c]pyridin-6(7H)-yl)(7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)methanone;

6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl)methanone;

[2-(Difluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-3-yl]-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

6,8-Dihydro-5H-imidazo[2,1-c][1,4]oxazin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

3,4-Dihydro-2H-pyrano[2,3-b]pyridin-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

3,4-Dihydro-2H-pyrano[2,3-b]pyridin-5-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

6,8-Dihydro-5H-pyrano[3,4-b]pyridin-4-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

6,8-Dihydro-5H-pyrano[3,4-b]pyridin-2-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

7,8-Dihydro-5H-pyrano[4,3-b]pyridin-3-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

3,4-Dihydro-2H-pyrano[3,2-b]pyridin-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazin-7-yl)methanone;

3,4-Dihydro-2H-pyrano[2,3-c]pyridin-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,2,3,4-tetrahydroisoquinolin-5-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1,2,3,4-tetrahydroisoquinolin-8-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isochroman-5-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isochroman-7-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isochroman-6-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-isochroman-8-yl-methanone;

Chroman-6-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazol[3,4-c]pyridin-6-yl]methanone;

Chroman-5-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazol[3,4-c]pyridin-6-yl]methanone;

Chroman-7-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazol[3,4-c]pyridin-6-yl]methanone;

Chroman-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

4-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one;

4-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3-methyl-1,3-benzoxazol-2-one;

5-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one;

7-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one;

6-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3H-1,3-benzoxazol-2-one;

7-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-3-methyl-1,3-benzoxazol-2-one;

7-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-4-methyl-1,4-benzoxazin-3-one;

[(7S)-2,7-8-[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridine-6-carbonyl]-4-methyl-1,4-benzoxazin-3-one;

3,4-Dihydro-2H-1,4-benzoxazin-8-yl-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-[3-(Difluoromethyl)-4-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

[(7S)-3-[3-(1,1-Difluoroethyl)phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

[(7S)-3-[3-(Difluoromethoxy)-4-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

Chroman-7-yl-[(7S)-3-[3-(difluoromethoxy)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-[3-(Difluoromethoxy)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

[(7S)-3-(4-Fluoro-3-methyl-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-methoxy-2-methyl-4-pyridyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-methyl-4-phenyl-imidazol-2-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(1-phenylimidazol-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-[3-methyl-2-(2-pyridyl)imidazol-4-yl]methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-fluoro-6-pyrazol-1-yl-phenyl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-spiro[3,4-dihydro-1,4-benzoxazine-2,1′-cyclopropane]-8-yl-methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(9-methylpurin-6-yl)methanone;

[(7S)-2,7-Dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(3-fluoro-5-methoxy-4-pyridyl)methanone;

(3-Chloro-4-methoxy-2-pyridyl)-[(7S)-3-[3-(difluoromethyl)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-[3-(Difluoromethyl)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

Chroman-7-yl-[(7S)-3-[3-(difluoromethyl)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

Chroman-7-yl-[(7S)-3-(3-fluoro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

(3-Chloro-4-methoxy-2-pyridyl)-[(7S)-3-[3-(difluoromethoxy)-5-fluoro-phenyl]-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

[(7S)-3-(3-Fluoro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]-(2-methoxy-3-methyl-4-pyridyl)methanone;

(3-Chloro-4-methoxy-2-pyridyl)-[(7S)-3-(3-fluoro-5-methoxy-phenyl)-2,7-dimethyl-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl]methanone;

racemic-(2-(Bicyclo[1.1.1]pentan-1-yl)-7-methyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl)methanone;

(R*)-(2-(Bicyclo[1.1.1]pentan-1-yl)-7-methyl-3-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)(5-cyclopropyl-1-methyl-1H-pyrazol-4-yl)methanone;

((S)-(1,6-Dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)(2,7-dimethyl-3-(3,4,5-trifluorophenyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)methanone; and

Cyclopropyl-2-methyl-imidazo[1,2-a] pyridin-3-yl)-[(7S)-2,7-dimethyl-3-(3,4,5-trifluorophenyl)-5,7-dihydro-4H-pyrazolo[3,4-c]pyridin-6-yl] methanone;

and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof.

84 . A compound selected from the group consisting of:

and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers.

85 . A pharmaceutical composition comprising:

(A) a therapeutically effective amount of at least one compound of Formula (II):

wherein

R 1 is C 1-4 alkyl;

R 2a is selected from the group consisting of:

(b) 6-Membered heteroaryl selected from the group consisting of:

(d) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

(e) Fused 6,6 heteroaryl selected from the group consisting of:

and

(f) Heterocycloalkyl selected from the group consisting of:

R 3a is selected from the group consisting of:

(g) Phenyl; or phenyl substituted with one, two, or three members each independently selected from the group consisting of: halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-6 haloalkyl;

(h) 5-Membered heteroaryl selected from the group consisting of:

(i) 6-Membered heteroaryl selected from the group consisting of:

(j) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

and

(k) Heterocycloalkyl selected from the group consisting of:

R f is selected from the group consisting of: H, halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R g is selected from the group consisting of: OC 1-4 alkyl, OC 1-4 haloalkyl, CH 2 OCH 3 , CH 2 OH,

R h is selected from the group consisting of: H, C 1-4 alkyl, C 1-4 haloalkyl, and C 3-6 cycloalkyl;

R j is selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 haloalkyl;

R k is selected from the group consisting of: H, halo, OH, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R m is H or C 1-4 alkyl;

R n is selected from the group consisting of: H, halo and OC 1-4 alkyl;

R o is selected from the group consisting of: H, C 1-4 alkyl, and C 1-4 haloalkyl;

R p is selected from the group consisting of: H, C 1-4 alkyl, and OC 1-4 alkyl;

Y is CH or N; and

R 4a is selected from the group consisting of: CH 3 , CF 2 H, CF 3 , C 3-6 cycloalkyl, and phenyl;

and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers of compounds of Formula (II); and

(B) at least one pharmaceutically acceptable excipient.

86 - 87 . (canceled)

88 . A method of treating a subject suffering from or diagnosed with a disease, disorder, or condition mediated by MGL receptor activity, comprising administering to a subject in need of such treatment a therapeutically effective amount of at least one compound of Formula (II):

wherein

R 1 is C 1-4 alkyl;

R 2a is selected from the group consisting of:

(b) 6-Membered heteroaryl selected from the group consisting of:

(d) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

(e) Fused 6,6 heteroaryl selected from the group consisting of:

(f) Heterocycloalkyl selected from the group consisting of:

R 3a is selected from the group consisting of:

(g) Phenyl; or phenyl substituted with one, two, or three members each independently selected from the group consisting of: halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-6 haloalkyl;

(h) 5-Membered heteroaryl selected from the group consisting of:

(i) 6-Membered heteroaryl selected from the group consisting of:

(j) 5,6-Fused or 6,5-fused heteroaryl selected from the group consisting of:

and

(k) Heterocycloalkyl selected from the group consisting of:

R f is selected from the group consisting of: H, halo, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R g is selected from the group consisting of: OC 1-4 alkyl, OC 1-4 haloalkyl, CH 2 OCH 3 ,

R h is selected from the group consisting of: H, C 1-4 alkyl, C 1-4 haloalkyl, and C 3-6 cycloalkyl;

R j is selected from the group consisting of: H, halo, C 1-4 alkyl and C 1-4 haloalkyl;

R k is selected from the group consisting of: H, halo, OH, C 1-4 alkyl, C 1-4 haloalkyl, OC 1-4 alkyl, and OC 1-4 haloalkyl;

R m is H or C 1-4 alkyl;

R n is selected from the group consisting of: H, halo and OC 1-4 alkyl;

R o is selected from the group consisting of: H, C 1-4 alkyl, and C 1-4 haloalkyl;

R p is selected from the group consisting of: H, C 1-4 alkyl, and OC 1-4 alkyl;

Y is CH or N; and

R 4a is selected from the group consisting of: CH 3 , CF 2 H, CF 3 , C 3-6 cycloalkyl, and phenyl;

and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers of compounds of Formula (II).

89 - 91 . (canceled)

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 2, 2019

From: AMERIKS, MICHAEL K.; CHEN, GANG; HUANG, CHAOFENG; LAFORTEZA, BRIAN NGO; RAVULA, SUCHITRA; SOUTHGATE, EMMA HELEN; ZHANG, WEI

To: JANSSEN PHARMACEUTICA NV

Reel/Frame 050608/0682 →