Granted Patent
B2
US 11,407,751 · App. 16/594,603 · Granted Aug 9, 2022
Hydrochloric acid salt of (6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
Inventors:
John Charles Tomesch (Succasunna, NJ); Peng Li (New Milford, NJ); Qiang Zhang (Somerset, NJ); Andrew S. Thompson (Mountainside, NJ)
Assignee:
INTRA-CELLULAR THERAPIES, INC.
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Abstract
The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, such as Formula 2J, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, and as further defined herein:
Claims (10)
1. A hydrochloric acid salt of a compound according to Formula 1I or Formula 2I:
wherein:
k is 1;
m is 1;
n is 1;
R 5 is H;
R 6a and R 6b are independently H;
R 7 , R 8 , and R 9 are independently H;
R 10 is CH 3 ; and
X is —N—.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 21, 2022
From: WENNOGLE, LAWRENCE P.
To: INTRA-CELLULAR THERAPIES, INC.
Reel/Frame 059666/0753 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 20, 2022
From: TOMESCH, JOHN CHARLES; LI, PENG; YAO, WEI; ZHANG, QIANG; BEARD, JAMES DAVID; THOMPSON, ANDREW; CHENG, HUA
To: INTRA-CELLULAR THERAPIES, INC.
Reel/Frame 059653/0620 →
Continuity (9)
Division
12531016
Provisional Application
60906473
· Mar 12, 2007