Cryoprotectant for use with a treatment device for improved cooling of subcutaneous lipid-rich cells

1. A system for selectively destroying subcutaneous lipid rich cells of a target region of a subject with skin, comprising:

a thermoelectric treatment device having

a fluid-cooled heat-exchanger,

a thermoelectric cooler having a backside substantially covered by the fluid-cooled heat-exchanger,

a heat exchanging element having a first side in thermal communication with a heat exchanging surface and a second side opposite the first side in thermal communication with a front side of the thermoelectric cooler, the heat exchanging element being configured to reduce a temperature of the target region for up to about 30 minutes such that lipid rich cells in the region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface;

a housing having an opening configured to receive the fluid-cooled heat-exchanger and thermoelectric cooler such that a sidewall of housing surrounds the fluid-cooled heat-exchanger and thermoelectric cooler;

at least one fluid line extending though an opening in the housing and in fluid communication with the fluid-cooled heat-exchanger, and

an absorbent configured to be positioned at least partially between the heat exchanging surface and the subject's skin and is configured to be thermally coupled to the treatment device, the absorbent being preloaded with an excess of cryoprotectant to continually supply the excess of cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced, wherein the cryoprotectant comprises about 40% propylene glycol and further comprises about 0.8% hydroxyethylcellulose.

2. The system of claim 1 , wherein the heat exchanging element reaches a temperature of about −20° C.

3. The system of claim 1 , wherein the absorbent is a cotton pad or a gauze to continually supply the cryoprotectant.

4. The system of claim 1 , wherein the cryoprotectant includes a viscosity that is in the range of about 1 cP to about 4,000 cP.

5. The system of claim 1 , wherein the absorbent is configured to substantially cover an interface between the treatment device and the skin, wherein the absorbent is configured to contact at least one of the treatment device and the skin.

6. The system of claim 5 , wherein the cryoprotectant further comprises a pH buffer to maintain the pH in the range of about 3 to about 11.

7. The system of claim 5 , wherein the cryoprotectant is water-soluble.

8. The system of claim 5 , wherein the cryoprotectant includes a viscosity in the range of about 1 cP to about 10,000 cP.

9. The system of claim 5 , wherein the cryoprotectant has a freezing point below about −10° C.

10. The system of claim 1 , wherein the excess of cryoprotectant preloaded onto the absorbent is configured to continually supply the cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced in light of absorption of the cryoprotectant by the skin.

11. The system of claim 1 , wherein the cryoprotectant has a freezing point below about −20° C.

12. A system for removing heat from subcutaneous lipid rich cells of a target region of a subject having skin, comprising:

a treatment device having a housing and a thermal mass in thermal communication with a heat exchanging surface, the thermal mass being configured to reduce a temperature of the target region for up to about 30 minutes such that lipid rich cells in the target region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface;

an absorbent configured to be positioned at least partially between the heat exchanging surface and the subject's skin, the absorbent being preloaded with an excess of a cryoprotectant to continually supply the excess of cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced, wherein the cryoprotectant comprises about 40% propylene glycol and further comprises 0.8% hydroxyethylcellulose.

13. The system of claim 12 , wherein the absorbent is configured to substantially cover an interface between the treatment device and the skin, wherein the absorbent is configured to contact at least one of the treatment device and the skin.

14. The system of claim 13 wherein the cryoprotectant further comprises a pH buffer to maintain the pH in the range of about 3 to about 11.

15. The system of claim 13 wherein the cryoprotectant is water-soluble.

16. The system of claim 13 wherein the cryoprotectant includes a viscosity in the range of about 1 cP to about 10,000 cP.

17. The system of claim 13 wherein the cryoprotectant has a freezing point below about −10° C.

18. The system of claim 12 , wherein the heat exchanging surface reaches a temperature of about −20° C.

19. The system of claim 12 , wherein the absorbent is a cotton pad or a gauze to continually supply the cryoprotectant.

20. The system of claim 12 , wherein the cryoprotectant includes a viscosity that is in the range of about 1 cP to about 4,000 cP.

21. The system of claim 12 , wherein the cryoprotectant has a freezing point below about −20° C.

22. The system of claim 12 , wherein the excess of cryoprotectant preloaded onto the absorbent is configured to continually supply the cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced in light of absorption of the cryoprotectant by the skin.

23. A system for selectively destroying subcutaneous lipid rich cells of a target region of a subject with skin, comprising:

a thermoelectric treatment device comprising:

a fluid-cooled heat-exchanger;

a thermoelectric cooler having a backside substantially covered by the fluid-cooled heat-exchanger; and

a heat exchanging element having a first side in thermal communication with a heat exchanging surface and a second side opposite the first side in thermal communication with a front side of the thermoelectric cooler, the heat exchanging element being configured to reduce a temperature of the target region for up to about 30 minutes such that lipid rich cells in the region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface; and

an absorbent configured to be positioned at least partially between the heat exchanging surface and the subject's skin and is configured to be thermally coupled to the thermoelectric treatment device, the absorbent being preloaded with an excess of cryoprotectant to continually supply the excess of cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced, wherein the cryoprotectant comprises about 40% propylene glycol and further comprises about 0.8% hydroxyethylcellulose.

24. A system for selectively destroying subcutaneous lipid rich cells of a target region of a subject with skin, comprising:

a thermoelectric treatment device comprising a heat exchanging element having a first side in thermal communication with a heat exchanging surface and a second side opposite the first side in thermal communication with a thermoelectric cooler, the heat exchanging element being configured to reduce a temperature of the target region for up to about 30 minutes such that lipid rich cells in the region are affected while preserving non-lipid rich cells proximate to the heat exchanging surface; and

an absorbent configured to be positioned at least partially between the heat exchanging surface and the subject's skin and is configured to be thermally coupled to the thermoelectric treatment device, the absorbent being preloaded with an excess of cryoprotectant to continually supply the excess of cryoprotectant from the absorbent to the subject's skin during the up to about 30 minutes the temperature of the target region is reduced, wherein the cryoprotectant comprises about 40% propylene glycol and further comprises about 0.8% hydroxyethylcellulose.