IP Library › Granted Patent US 11,304,977
Granted Patent B2
US 11,304,977 · App. 16/598,418 · Granted Apr 19, 2022

Tumoricidal and antimicrobial compositions and methods

Inventors: Hans G. Klingemann (Boston, MA); Barry J. Simon (Culver City, CA)
Assignee: ImmunityBio. Inc.
A61K35/17A61K9/0014A61K9/0019A61K9/06A61K9/08A61K9/5068A61K38/2013C12N5/0646A61K2035/124
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Quick Facts
Patent No.
US 11,304,977
App. No.
16/598,418
Granted
Apr 19, 2022
Kind
B2
Abstract

Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.

Claims (5)

1. A composition for treating cancer comprising isolated exosomes or microvesicles from NK-92 cells cultured in a medium supplemented with at least one of a nutrient, a cytokine, or a growth factor.

2. The composition of claim 1 , wherein the medium comprises a cytokine and the cytokine is selected from the group consisting of IL-2, IL-15, interferon gamma and combinations thereof.

3. The composition of claim 1 , wherein the medium comprises a nutrient.

4. The composition of claim 1 , wherein the medium comprises a growth factor.

5. The composition of claim 1 , wherein the nutrient is selected from the group consisting of L-asparagine, L-glutamine, L-serine and combinations thereof.

Assignments (3)
SECURITY INTEREST Recorded Jan 2, 2024
From: IMMUNITYBIO, INC.; NANTCELL, INC.; RECEPTOME, INC.; VBC HOLDINGS LLC; ALTOR BIOSCIENCE, LLC; ETUBICS CORPORATION; IGDRASOL, INC.
To: INFINITY SA LLC, AS PURCHASER AGENT
Reel/Frame 066179/0074 →
CHANGE OF NAME Recorded Aug 2, 2021
From: NANTKWEST, INC.
To: IMMUNITYBIO, INC.
Reel/Frame 057059/0802 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2020
From: KLINGEMANN, HANS G.; SIMON, BARRY J.
To: NANTKWEST, INC.
Reel/Frame 053093/0414 →
Continuity (4)
Continuation 16289494 · Feb 28, 2019
Division 15032518
Provisional Application 61899066 · Nov 1, 2013
Related Publication 20200038445A1 · Feb 6, 2020