Short-acting benzodiazepine salts and their polymorphic forms
The invention relates to besylate salts of the compound of formula (I): Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.
1. A pharmaceutical composition comprising a besylate salt of the compound of formula (I)
and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein the pharmaceutical composition is an aqueous solution comprising dextrose or saline.
2. The pharmaceutical composition according to claim 1 , wherein the aqueous solution comprises saline.
3. The pharmaceutical composition according to claim 1 , wherein the aqueous solution comprises dextrose.
4. A lyophilized composition comprising a besylate salt of the compound of formula (I)
and at least one pharmaceutically acceptable carrier, excipient or diluent, and dextrose or saline.
5. An aqueous pharmaceutical composition comprising of the lyophilized composition of claim 4 .
6. The aqueous pharmaceutical composition according to claim 5 , wherein the aqueous solution comprises saline.
7. The aqueous pharmaceutical composition according to claim 5 , wherein the aqueous solution comprises dextrose.
8. A method of producing sedation in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a besylate salt of the compound of formula (I)
and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein the pharmaceutical composition is an aqueous solution comprising dextrose or saline.
9. The method according to claim 8 , wherein the aqueous solution comprises saline.
10. The method according to claim 8 , wherein the aqueous solution comprises dextrose.