Optical biomodule for detection of diseases at an early onset
View Patent ↗An optical biomodule for detecting a disease specific biomarker, utilizing an enhanced light emission due to integration of one or more three-dimensional (3-D) protruded structures in a fluidic container (which includes one or more materials), upon chemical binding of a disease specific biomarker binder (which includes a first segment coupled with a first fluorophore and a second segment coupled with a second fluorophore) with its corresponding disease specific biomarker is disclosed. Furthermore, the disease specific biomarker binder may include a synthetic biological logic circuit/gate. Furthermore, the three-dimensional (3-D) protruded structure can be coupled with a photonic crystal or a metamaterial (hyperbolic metamaterial/metamaterial of Epsilon-Near-Zero (ENZ)) of a suitable wavelength range.
1. An optical biomodule comprising:
(a) a fluidic container;
wherein a substrate of the fluidic container comprises one or more materials,
wherein the fluidic container comprises a biomarker binder to bind with a biomarker,
wherein the biomarker binder further comprises a first segment of the biomarker binder and a second segment of the biomarker binder,
wherein the first segment of the biomarker binder is coupled with a first fluorophore,
wherein the second segment of the biomarker binder is coupled with a second fluorophore,
wherein a distance between the first fluorophore and the second fluorophore is between 1 nanometer and 200 nanometers,
wherein the first segment of the biomarker binder couples with a first section of the biomarker,
wherein the second segment of the biomarker binder couples with a second section of the biomarker,
wherein the fluidic container comprises a plurality of three-dimensional (3-D) protruded structures,
wherein the three-dimensional (3-D) protruded structures are spaced or arranged in a one-dimensional (1-D) array, or in a two-dimensional (2-D) array,
wherein a pitch, or a gap, or a duty cycle of the one-dimensional (1-D) array, or the two-dimensional (2-D) array of the three-dimensional (3-D) protruded structures is varied for a maximum enhancement of a light emission due to an interaction of the first fluorophore and the second fluorophore,
(b) a light source, or light sources directed at the fluidic container for inducing the interaction between the first fluorophore and the second fluorophore; and
(c) a device for detecting the light emission due to the interaction between the first fluorophore and the second fluorophore from the fluidic container, wherein the device comprises a photodiode.
2. The optical biomodule according to claim 1 , wherein the first segment of the biomarker binder is replaced by a first biomarker binder device, wherein the first biomarker binder device comprises a first synthetic biological logic circuit, or a first synthetic biological logic gate.
3. The optical biomodule according to claim 1 , wherein the second segment of the biomarker binder is replaced by a second biomarker binder device, wherein the second biomarker binder device comprises a second synthetic biological logic circuit, or a second synthetic biological logic gate.
4. The optical biomodule according to claim 1 , wherein a dimension, or a shape of at least one of the three-dimensional (3-D) protruded structures is (i) geometrically outlined by a formula r(ρ, θ)=ρ(1+β cos(nθ)), wherein ρ=15 nm, β=⅔, n=5, and θ ranges from 0 degree angle to 360 degree angle, or (ii) an ellipse.
5. The optical biomodule according to claim 1 , wherein at least one of the three-dimensional (3-D) protruded structures is within a recessed closed cavity, or within a recessed open cavity.
6. The optical biomodule according to claim 1 , wherein at least one of the three-dimensional (3-D) protruded structures is an optical nanoantenna, or a nanotube.
7. The optical biomodule according to claim 1 , wherein at least one of the three-dimensional (3-D) protruded structures is (i) geometrically outlined by a shape of a tip, or (ii) a nanoparticle.
8. The optical biomodule according to claim 1 , wherein at least one of the three-dimensional (3-D) protruded structures is coupled with a photonic crystal, or a metamaterial, or a metamaterial of Epsilon-Near-Zero (ENZ), or a hyperbolic metamaterial.
9. The optical biomodule according to claim 1 , wherein at least one of the three-dimensional (3-D) protruded structures comprises a two-dimensional (2-D) material.
10. The optical biomodule according to claim 1 , wherein the light sources comprise a first coherent light source and a second coherent light source, wherein a laser beam of the first coherent light source has an open toroidal shape, wherein the first coherent light source and the second coherent light source are activated simultaneously.
11. The optical biomodule according to claim 1 , wherein the substrate of the fluidic container comprises periodic layers of the one or more materials.
12. The optical biomodule according to claim 1 , further comprising a heating element and a temperature control circuit.
13. The optical biomodule according to claim 1 , further comprising a microfluidic device.
14. An optical biomodule comprising:
(a) a fluidic container;
wherein a substrate of the fluidic container comprises one or more materials,
wherein the fluidic container comprises a biomarker binder to bind with a biomarker,
wherein the biomarker binder further comprises a first segment of the biomarker binder and a second segment of the biomarker binder,
wherein the first segment of the biomarker binder is coupled with a first fluorophore,
wherein the second segment of the biomarker binder is coupled with a second fluorophore,
wherein a distance between the first fluorophore and the second fluorophore is between 1 nanometer and 200 nanometers,
wherein the first segment of the biomarker binder couples with a first section of the biomarker,
wherein the second segment of the biomarker binder couples with a second section of the biomarker,
wherein the fluidic container comprises a plurality of three-dimensional (3-D) protruded structures,
wherein at least one of the three-dimensional (3-D) protruded structures is within a recessed closed cavity, or within a recessed open cavity,
wherein the three-dimensional (3-D) protruded structures are spaced or arranged in a one-dimensional (1-D) array, or in a two-dimensional (2-D) array,
wherein a pitch, or a gap, or a duty cycle of the one-dimensional (1-D) array, or the two-dimensional (2-D) array of the three-dimensional (3-D) protruded structures is varied for a maximum enhancement of a light emission due to an interaction of the first fluorophore and the second fluorophore,
(b) a light source, or light sources directed at the fluidic container for inducing the interaction between the first fluorophore and the second fluorophore; and
(c) a device for detecting the light emission due to the interaction between the first fluorophore and the second fluorophore from the fluidic container, wherein the device comprises a photodiode.
15. The optical biomodule according to claim 14 , wherein the first segment of the biomarker binder is replaced by a first biomarker binder device, wherein the first biomarker binder device comprises a first synthetic biological logic circuit, or a first synthetic biological logic gate.
16. The optical biomodule according to claim 14 , wherein the second segment of the biomarker binder is replaced by a second biomarker binder device, wherein the second biomarker binder device comprises a second synthetic biological logic circuit, or a second synthetic biological logic gate.
17. The optical biomodule according to claim 14 , wherein at least one of the three-dimensional (3-D) protruded structures is an optical nanoantenna, or a nanotube.
18. The optical biomodule according to claim 14 , wherein at least one of the three-dimensional (3-D) protruded structures is (i) geometrically outlined by a shape of a tip, or (ii) a nanoparticle.
19. The optical biomodule according to claim 14 , wherein at least one of the three-dimensional (3-D) protruded structures is coupled with a photonic crystal, or a metamaterial.
20. The optical biomodule according to claim 19 , wherein the metamaterial in claim 19 , is a metamaterial of Epsilon-Near-Zero (ENZ), or a hyperbolic metamaterial.
21. The optical biomodule according to claim 14 , wherein at least one of the three-dimensional (3-D) protruded structures comprises a two-dimensional (2-D) material.
22. The optical biomodule according to claim 14 , wherein the substrate of the fluidic container comprises periodic layers of the one or more materials.
23. An optical biomodule comprising:
(a) a fluidic container;
wherein a substrate of the fluidic container comprises one or more materials,
wherein the fluidic container comprises a biomarker binder to bind with a biomarker,
wherein the biomarker binder further comprises a first segment of the biomarker binder and a second segment of the biomarker binder,
wherein the first segment of the biomarker binder is coupled with a first fluorophore,
wherein the second segment of the biomarker binder is coupled with a second fluorophore,
wherein a distance between the first fluorophore and the second fluorophore is between 1 nanometer and 200 nanometers,
wherein the first segment of the biomarker binder couples with a first section of the biomarker,
wherein the second segment of the biomarker binder couples with a second section of the biomarker,
wherein the fluidic container comprises a plurality of three-dimensional (3-D) protruded structures,
wherein at least one of the three-dimensional (3-D) protruded structures is coupled with a photonic crystal, or a metamaterial,
wherein the three-dimensional (3-D) protruded structures are spaced or arranged in a one-dimensional (1-D) array, or in a two-dimensional (2-D) array,
wherein a pitch, or a gap, or a duty cycle of the one-dimensional (1-D) array, or the two-dimensional (2-D) array of the three-dimensional (3-D) protruded structures is varied for a maximum enhancement of a light emission due to an interaction of the first fluorophore and the second fluorophore,
(b) a light source, or light sources directed at the fluidic container for inducing the interaction between the first fluorophore and the second fluorophore; and
(c) a device for detecting the light emission due to the interaction between the first fluorophore and the second fluorophore from the fluidic container, wherein the device comprises a photodiode.
24. The optical biomodule according to claim 23 , wherein the first segment of the biomarker binder is replaced by a first biomarker binder device, wherein the first biomarker binder device comprises first synthetic biological logic circuit, or a first synthetic biological logic gate.
25. The optical biomodule according to claim 23 , wherein the second segment of the biomarker binder is replaced by a second biomarker binder device, wherein the second biomarker binder device comprises second synthetic biological logic circuit, or a second synthetic biological logic gate.
26. The optical biomodule according to claim 23 , wherein at least one of the three-dimensional (3-D) protruded structures is within a recessed closed cavity, or within a recessed open cavity.
27. The optical biomodule according to claim 23 , wherein at least one of the three-dimensional (3-D) protruded structures is an optical nanoantenna, or a nanotube.
28. The optical biomodule according to claim 23 , wherein at least one of the three-dimensional (3-D) protruded structures is (i) geometrically outlined by a shape of a tip, or (ii) a nanoparticle.
29. The optical biomodule according to claim 23 , wherein at least one of the three-dimensional (3-D) protruded structures comprises a two-dimensional (2-D) material.
30. The optical biomodule according to claim 23 , wherein the metamaterial is a metamaterial of Epsilon-Near-Zero (ENZ), or a hyperbolic metamaterial.
31. The optical biomodule according to claim 23 , wherein the substrate of the fluidic container comprises periodic layers of the one or more materials.