Composition for use in the treatment of epilepsy
A composition comprising a decanoic acid to octanoic acid ratio of 70:30 to 90:10 wt/wt for use in treating epilepsy or controlling epileptic seizures.
1. A method of treating epilepsy or controlling epileptic seizures in an individual in need thereof, the method comprising administering to the individual a composition comprising a decanoic acid to octanoic acid ratio of 71:29 to 89:11 wt/wt.
2. The method according to claim 1 , wherein the decanoic acid to octanoic acid ratio is 80:20 wt/wt.
3. The method according to claim 1 , wherein the decanoic acid and the octanoic acid are in a form of triglycerides.
4. The method according to claim 1 , wherein the composition is in a form selected from the group consisting of a medical food, a tube feed, a nutritional composition and a nutritional supplement.
5. The method according to claim 1 , wherein the octanoic acid and the decanoic acid are at least 80% of a total fatty acid content of the composition.
6. The method according to claim 1 , wherein the composition further comprises at least one substance selected from the group consisting of minerals, vitamins, salts, preservatives, and combinations thereof.
7. The method according to claim 1 , wherein the composition has a total fat content to protein/carbohydrate content ratio of 1:1 to 7:1.
8. A method of reducing excitatory post-synaptic currents (EPSCs) in a subject with epilepsy, the method comprising administering to the subject a composition comprising a decanoic acid to octanoic acid ratio of 71:29 to 89:11 wt/wt.
9. The method according to claim 8 , wherein the decanoic acid to octanoic acid ratio is 80:20 wt/wt.
10. The method according to claim 8 , wherein the decanoic acid and the octanoic acid are in a form of triglycerides.
11. The method according to claim 8 , wherein the composition is in a form selected from the group consisting of a medical food, a tube feed, a nutritional composition and a nutritional supplement.
12. The method according to claim 8 , wherein the octanoic acid and the decanoic acid are at least 80% of a total fatty acid content of the composition.
13. A method of inhibiting α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in a subject in need thereof, the method comprising administering to the subject a composition comprising a decanoic acid to octanoic acid ratio of 71:29 to 89:11 wt/wt.
14. The method according to claim 13 , wherein the decanoic acid to octanoic acid ratio is 80:20 wt/wt.
15. The method according to claim 13 , wherein the decanoic acid and the octanoic acid are in a form of triglycerides.
16. The method according to claim 13 , wherein the composition is in a form selected from the group consisting of a medical food, a tube feed, a nutritional composition and a nutritional supplement.
17. The method according to claim 13 , wherein the octanoic acid and the decanoic acid are at least 80% of a total fatty acid content of the composition.