Antidotes to cyanide poisoning
The present application provides, inter alia, a compound of Formula (I): or a pharmaceutically acceptable salt thereof, and methods of use of the compound of Formula (I) for treatment and prevention of cyanide poisoning.
1. A unit dosage form comprising:
(i) a compound selected from:
or a pharmaceutically acceptable salt thereof, and
(ii) a pharmaceutically acceptable carrier,
wherein the unit dosage form is in the form of a tablet, capsule, or ampule suitable for direct administration to a subject, and
wherein the unit dosage form comprises a therapeutically effective amount to provide protection against cyanide poisoning.
2. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
3. The pharmaceutical composition of claim 2 , wherein the compound is selected from:
4. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
5. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6. The pharmaceutical composition of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is suitable for administration by an intramuscular injection.