IP Library › Granted Patent US 11,559,508
Granted Patent B2
US 11,559,508 · App. 16/606,520 · Granted Jan 24, 2023

Pharmaceutical compositions comprising POH derivatives and methods of use

Inventors: Thomas Chen (La Canada, CA); Daniel Levin (La Canada, CA); Satish Puppali (Rancho Cucamonga, CA)
Assignee: NEONC TECHNOLOGIES, INC.
A61K31/20A61K9/0043A61K31/045A61K45/06A61K47/55
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Quick Facts
Patent No.
US 11,559,508
App. No.
16/606,520
Granted
Jan 24, 2023
Kind
B2
Abstract

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Claims (3)

1. A pharmaceutical composition comprising a perillyl alcohol conjugated with valproic acid.

2. The pharmaceutical composition of claim 1 , wherein the perillyl alcohol conjugated with valproic acid is an ester of perillyl alcohol with valproic acid.

3. The pharmaceutical composition of claim 2 , wherein the ester is 2-Propylpentanoic acid 4-isopropenyl-cyclohex-1-enylmethyl ester.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 23, 2023
From: NEONC TECHNOLOGIES INC.
To: UNIVERSITY OF SOUTHERN CALIFORNIA
Reel/Frame 063726/0859 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 3, 2020
From: CHEN, THOMAS; LEVIN, DANIEL; PUPALLI, SATISH
To: NEONC TECHNOLOGIES, INC.
Reel/Frame 052303/0024 →
Continuity (2)
Provisional Application 62487339 · Apr 19, 2017
Related Publication 20200237697A1 · Jul 30, 2020