Biodegradable bone glue
The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
1. A bioresorbable polymer of Formula I
wherein:
R is:
wherein:
m is between 4 and 90;
n is between 5 and 200;
x is between 1 and 200; and
y is between 0 and 200.
2. A composition comprising:
a bioresorbable polymer of Formula I of claim 1 , or a mixture thereof;
a solvent; and
a non-solvent.
3. The composition of claim 2 , wherein the composition further comprises an additive.
4. The composition of claim 3 , wherein the additive is dissolved in the non-solvent.
5. The composition of claim 2 , wherein the composition further comprises an antimicrobial agent, antibacterial agent, or a mixture thereof.
6. The composition of claim 2 , wherein the solvent is acetone, chloroform, dichloromethane, dimethylsulfoxide, dimethyl formamide, polyethylene glycol or N-Methyl-2-Pyrrolidone.
7. The composition of claim 2 , wherein the non-solvent is ethanol, methanol, water, cyclohexane, hexane, pentane, hydrogen peroxide, diethyl ether, tert-butyl methyl ether (TBME), phosphate buffer saline solution (PBS) or a mixture thereof.
8. The composition of claim 3 , wherein the additive is a growth factor, a vitamin, a biologic, an antibiotic, an antiviral agent, Alendronate, Olpadronate, Etidronate, polyethylene glycol, a polyamino acid, an aliphatic polyester, a saccharide, an aliphatic polycarbonate, a poly amine, a polyanhydride, a steroid, glycerol, ascorbic acid, an amino acid, or a peptide, an inorganic particle, poly-ethyleneimine (PEI), poly-l-lysine (PLL), poly-d-lysine (PDL), poly-d,l-lysine (PDLL), poly-l-cysteine, poly-d-cysteine, poly-d,l-cysteine, short oligomers of l-lysine, d-lysine, I-cysteine, d-cysteine, an amino functionalized PEG, an amino functionalized inorganic particle, and a tin catalyst.